User profiles for R. Carballar-Lejarazu

Rebeca Carballar Lejarazú

University of California Irvine
Verified email at uci.edu
Cited by 1202

Population modification of Anopheline species to control malaria transmission

R Carballar-Lejarazú, AA James - Pathogens and global health, 2017 - Taylor & Francis
Vector control strategies based on population modification of Anopheline mosquitoes may
have a significant role in the malaria eradication agenda. They could consolidate elimination …

Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae

R Carballar-Lejarazú, C Ogaugwu… - Proceedings of the …, 2020 - National Acad Sciences
A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver antiparasite
effector molecules to the malaria vector mosquito, Anopheles gambiae. The drive system …

[HTML][HTML] Comparative genomics shows that viral integrations are abundant and express piRNAs in the arboviral vectors Aedes aegypti and Aedes albopictus

U Palatini, P Miesen, R Carballar-Lejarazu, L Ometto… - BMC genomics, 2017 - Springer
Background Arthropod-borne viruses (arboviruses) transmitted by mosquito vectors cause
many important emerging or resurging infectious diseases in humans including dengue, …

Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii

R Carballar-Lejarazú, Y Dong… - Proceedings of the …, 2023 - National Acad Sciences
Proposed genetic approaches for reducing human malaria include population modification,
which introduces genes into vector mosquitoes to reduce or prevent parasite transmission. …

[HTML][HTML] Global governing bodies: a pathway for gene drive governance for vector mosquito control

…, J Murphy, S Firth, R Carballar-Lejarazú - The American Journal …, 2020 - ncbi.nlm.nih.gov
Gene drive technologies represent powerful tools to develop vector control strategies that
will complement the current approaches to mitigate arthropod-borne infectious diseases. The …

[HTML][HTML] Experimental population modification of the malaria vector mosquito, Anopheles stephensi

…, D Stillinger, JM Marshall, R Carballar-Lejarazú… - PLoS …, 2019 - journals.plos.org
Small laboratory cage trials of non-drive and gene-drive strains of the Asian malaria vector
mosquito, Anopheles stephensi, were used to investigate release ratios and other strain …

Population genomics in the arboviral vector Aedes aegypti reveals the genomic architecture and evolution of endogenous viral elements

…, D Ayala, C Paupy, R CarballarLejarazu… - Molecular …, 2021 - Wiley Online Library
Horizontal gene transfer from viruses to eukaryotic cells is a pervasive phenomenon. Somatic
viral integrations are linked to persistent viral infection whereas integrations into germline …

[HTML][HTML] Integrated proteomic and transcriptomic analysis of the Aedes aegyptieggshell

…, B Nguyen, J Juhn, R Carballar-Lejarazú… - BMC Developmental …, 2014 - Springer
… B) Ovary (Ov) and eggshell (ES) protein preparations dissolved in SDS/β-mercaptoethanol
buffer resolved using 4–15% SDS-PAGE and stained with Coomassie blue R. The …

Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes

…, TB Pham, A Kelsey, R Carballar-Lejarazú… - Insect Biochemistry and …, 2022 - Elsevier
Insect ommochrome biosynthesis pathways metabolize tryptophan to generate eye-color
pigments and wild-type alleles of pathway genes are useful phenotypic markers in …

[HTML][HTML] Selection and evaluation of reference genes for qRT-PCR analysis in Euscaphis konishii Hayata based on transcriptome data

W Liang, X Zou, R Carballar-Lejarazú, L Wu, W Sun… - Plant Methods, 2018 - Springer
Background Quantitative real-time reverse transcription-polymerase chain reaction has been
widely used in gene expression analysis, however, to have reliable and accurate results, …