User profiles for R. Beroukhim

Rameen Beroukhim

Dana-Farber Cancer Institute, Harvard Medical School
Verified email at broadinstitute.org
Cited by 169994

Genomic evolution of cancer models: perils and opportunities

U Ben-David, R Beroukhim, TR Golub - Nature Reviews Cancer, 2019 - nature.com
Cancer research relies on model systems, which reflect the biology of actual human tumours
to only a certain extent. One important feature of human cancer is its intra-tumour genomic …

Medical therapies for meningiomas

PY Wen, E Quant, J Drappatz, R Beroukhim… - Journal of neuro …, 2010 - Springer
Meningiomas are the most common primary brain tumor in adults. Although the majority of
these tumors can be effectively treated with surgery and radiation therapy, an important …

[HTML][HTML] The somatic genomic landscape of glioblastoma

…, D Chakravarty, JZ Sanborn, SH Berman, R Beroukhim… - cell, 2013 - cell.com
We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

The landscape of somatic copy-number alteration across human cancers

R Beroukhim, CH Mermel, D Porter, G Wei… - Nature, 2010 - nature.com
A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…

[PDF][PDF] Genomic classification of cutaneous melanoma

…, D Belyaev, C Benz, B Bernard, R Beroukhim… - Cell, 2015 - cell.com
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

[PDF][PDF] The molecular taxonomy of primary prostate cancer

…, T Bauer, CC Benz, A Bergeron, R Beroukhim… - Cell, 2015 - cell.com
R. Beroukhim is a consultant for and received grant funding from Novartis. M. Meyerson
received research support from Bayer and has equity in and is a consultant for Foundation …

[PDF][PDF] Integrated genomic characterization of papillary thyroid carcinoma

…, S Balu, SB Baylin, M Behera, B Bernard, R Beroukhim… - Cell, 2014 - cell.com
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics

…, N Thiessen, K Tse, T Wong, AC Berger, R Beroukhim… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …

Structural variations in cancer and the 3D genome

…, N Sidiropoulos, J Weischenfeldt, R Beroukhim - Nature Reviews …, 2022 - nature.com
Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …

[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer

…, N Thiessen, K Tse, T Wong, AC Berger, R Beroukhim… - Cell, 2018 - cell.com
… dichotomized the data using a b-value of R 0.3 to define positive DNA methylation and < 0.3
… CpG sites that were methylated at a b-value of R 0.3 in more than 10% of tumors within any …