Human cancers, including breast cancers, comprise clones differing in mutation content.
Clones evolve dynamically in space and time following principles of Darwinian evolution 1 , 2 , …

The genomes of large numbers of single cells must be sequenced to further understanding
of the biological significance of genomic heterogeneity in complex systems. Whole genome …

The post-genomic era presents many new challenges for the field of bioinformatics. Novel
computational approaches are now being developed to handle the large, complex and noisy …

We studied the whole-genome point mutation and structural variation patterns of 133 tumors
(59 high-grade serous (HGSC), 35 clear cell (CCOC), 29 endometrioid (ENOC), and 10 …

Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and
is often found contiguous with these cancers. Using whole‐genome shotgun sequencing of …

Background Accumulating evidence indicates that an early, robust type 1 interferon (IFN)
response to SARS-CoV-2 is important in determining COVID-19 outcomes, with an inadequate …

Background SARS-CoV-2 infection rapidly spreads in populations due to the high rates of
community transmission. Interrupting the shedding of SARS-CoV-2 may reduce the incidence …

Infectious disease and sepsis represent a serious problem for all, but especially in early life.
Much of the increase in morbidity and mortality due to infection in early life is presumed to …

Background: The field of next-generation sequencing informatics has matured to a point
where algorithmic advances in sequence alignment and individual feature detection methods …

… Next, we assessed enrichment of GO biological processes amongst the targets of an enhancer
cluster using R’s GOstats package. Enhancer clusters also revealed consistently greater …