We identified a seven-pass transmembrane receptor of the cadherin superfamily, designated
Flamingo (Fmi), localized at cell–cell boundaries in the Drosophila wing. In the absence of …

The development of chemical synapses is regulated by interactions between pre- and
postsynaptic cells. At the vertebrate skeletal neuromuscular junction, the organization of an …

Neuronal mitochondria regulate synaptic physiology and cellular survival, and disruption of
their function or transport causes neurological disease. We present a fluorescence method to …

Activity-dependent and -independent signals collaborate to regulate synaptogenesis, but
their relative contributions are unclear. Here, we describe the formation of neuromuscular …

Synaptic activity drives synaptic rearrangement in the vertebrate nervous system; indeed,
this appears to be a main way in which experience shapes neural connectivity 1 , 2 . One …

To establish functional circuitry, retinal neurons occupy spatial domains by arborizing their
processes, which requires the self-avoidance of neurites from an individual cell, and by …

Of the many inherited Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) is
caused by dominant point mutations in the gene GARS, encoding glycyl tRNA synthetase (…

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DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including
axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell …

Agrin induces synaptic differentiation at the skeletal neuromuscular junction (NMJ); both pre-
and postsynaptic differentiation are drastically impaired in its absence. Multiple …