User profiles for R. T. Libby

Richard T Libby

University of Rochester
Verified email at urmc.rochester.edu
Cited by 8568

Glaucoma: thinking in new ways—a role for autonomous axonal self-destruction and other compartmentalised processes?

AV Whitmore, RT Libby, SWM John - Progress in retinal and eye research, 2005 - Elsevier
… At least 10% of RGC axons may follow a tortuous route such as that shown here, making
them particularly vulnerable to the effects of relative movements of the laminar plates (leading …

Complex genetics of glaucoma susceptibility

RT Libby, DB Gould, MG Anderson… - Annu. Rev. Genomics …, 2005 - annualreviews.org
Libby, pp 15-44 … For simplicity, we represent the trabecular pathway in this review with
the understanding that any effects on the uveoscleral route must also be considered. …

A short polypeptide marker sequence useful for recombinant protein identification and purification

TP Hopp, KS Prickett, VL Price, RT Libby, CJ March… - Bio/technology, 1988 - nature.com
A small hydrophilic peptide of eight amino acids (AspTyrLysAspAspAspAspLys) was engineered
onto the N-terminus of a variety of recombinant lymphokines for the purpose of aiding in …

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

GR Howell, I Soto, RT Libby, SWM John - Experimental neurology, 2013 - Elsevier
… In a recent study, we found that activated JNK was present at the site of injury soon after
mechanical injury to RGC axons (Libby, unpublished observations). Genetic ablation of JNK 2 …

[HTML][HTML] Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

P Weydt, VV Pineda, AE Torrence, RT Libby… - Cell metabolism, 2006 - cell.com
… We performed real-time RT-PCR analysis of BAT RNAs obtained from sets of 20-week-old
HD … Real-time RT-PCR of the BAT samples shown in (A) was performed for UCP-1. WT mice …

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

GR Howell, RT Libby, TC Jakobs, RS Smith… - The Journal of cell …, 2007 - rupress.org
… GR Howell and RT Libby contributed equally to this work. RT Libby's present address is
University of Rochester Eye Institute, … GR Howell and RT Libby contributed equally to this work. …

[HTML][HTML] Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

…, BA Barres, AF Clark, RT Libby… - The Journal of …, 2011 - Am Soc Clin Investig
Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest
stages of this complex disease are still unclear. This study was specifically designed to …

Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration

RT Libby, MG Anderson, I Pang, ZH Robinson… - Visual …, 2005 - cambridge.org
… Thus, we conclude that the only substantial neuronal loss is from the RGC population ~Libby
et al., 2005b!. ONL: outer nuclear layer; INL: inner nuclear layer; and GCL: ganglion cell …

[HTML][HTML] Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage

RT Libby, Y Li, OV Savinova, J Barter, RS Smith… - PLoS …, 2005 - journals.plos.org
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It
is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the …

Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice

TC Jakobs, RT Libby, Y Ben, SWM John… - The Journal of cell …, 2005 - rupress.org
Using a variety of double and triple labeling techniques, we have reevaluated the death of
retinal neurons in a mouse model of hereditary glaucoma. Cell-specific markers and total …