User profiles for R. T. Libby
Richard T LibbyUniversity of Rochester Verified email at urmc.rochester.edu Cited by 8568 |
Glaucoma: thinking in new ways—a role for autonomous axonal self-destruction and other compartmentalised processes?
… At least 10% of RGC axons may follow a tortuous route such as that shown here, making
them particularly vulnerable to the effects of relative movements of the laminar plates (leading …
them particularly vulnerable to the effects of relative movements of the laminar plates (leading …
Complex genetics of glaucoma susceptibility
… Libby, pp 15-44 … For simplicity, we represent the trabecular pathway in this review with
the understanding that any effects on the uveoscleral route must also be considered. …
the understanding that any effects on the uveoscleral route must also be considered. …
A short polypeptide marker sequence useful for recombinant protein identification and purification
TP Hopp, KS Prickett, VL Price, RT Libby, CJ March… - Bio/technology, 1988 - nature.com
A small hydrophilic peptide of eight amino acids (AspTyrLysAspAspAspAspLys) was engineered
onto the N-terminus of a variety of recombinant lymphokines for the purpose of aiding in …
onto the N-terminus of a variety of recombinant lymphokines for the purpose of aiding in …
Intrinsic axonal degeneration pathways are critical for glaucomatous damage
… In a recent study, we found that activated JNK was present at the site of injury soon after
mechanical injury to RGC axons (Libby, unpublished observations). Genetic ablation of JNK 2 …
mechanical injury to RGC axons (Libby, unpublished observations). Genetic ablation of JNK 2 …
[HTML][HTML] Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
P Weydt, VV Pineda, AE Torrence, RT Libby… - Cell metabolism, 2006 - cell.com
… We performed real-time RT-PCR analysis of BAT RNAs obtained from sets of 20-week-old
HD … Real-time RT-PCR of the BAT samples shown in (A) was performed for UCP-1. WT mice …
HD … Real-time RT-PCR of the BAT samples shown in (A) was performed for UCP-1. WT mice …
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
… GR Howell and RT Libby contributed equally to this work. RT Libby's present address is
University of Rochester Eye Institute, … GR Howell and RT Libby contributed equally to this work. …
University of Rochester Eye Institute, … GR Howell and RT Libby contributed equally to this work. …
[HTML][HTML] Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest
stages of this complex disease are still unclear. This study was specifically designed to …
stages of this complex disease are still unclear. This study was specifically designed to …
Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
… Thus, we conclude that the only substantial neuronal loss is from the RGC population ~Libby
et al., 2005b!. ONL: outer nuclear layer; INL: inner nuclear layer; and GCL: ganglion cell …
et al., 2005b!. ONL: outer nuclear layer; INL: inner nuclear layer; and GCL: ganglion cell …
[HTML][HTML] Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage
RT Libby, Y Li, OV Savinova, J Barter, RS Smith… - PLoS …, 2005 - journals.plos.org
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It
is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the …
is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the …
Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
Using a variety of double and triple labeling techniques, we have reevaluated the death of
retinal neurons in a mouse model of hereditary glaucoma. Cell-specific markers and total …
retinal neurons in a mouse model of hereditary glaucoma. Cell-specific markers and total …