Competing theories seek to account for the therapeutic effects of high-frequency deep brain
stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's …

Although there is general consensus that deep brain stimulation (DBS) yields substantial
clinical benefit in patients with Parkinson's disease (PD), the therapeutic mechanism of DBS …

The cortico-basal ganglia pathway is involved in normal motor control and implicated in
multiple movement disorders. Brief repetitive muscle contractions known as motor tics are a …

Comparative studies of the divergence of quantitative traits and neutral molecular markers,
known as Q ST –F ST comparisons, provide a means for researchers to distinguish between …

An important aspect of motor skill lies in the ability to acquire and utilize representations of
ordered sequences of motor acts, thereby allowing one to select and execute a sequence of …

The current model of basal ganglia organization postulates the existence of a functional
partitioning into sensorimotor, associative and limbic territories, implicated in motor, cognitive …

Motor tics, a cardinal symptom of Tourette syndrome (TS), are hypothesized to arise from
abnormalities within cerebro-basal ganglia circuits. Yet noninvasive neuroimaging of TS has …

Object The authors sought to examine the therapeutic efficacy of motor cortex stimulation (MCS)
in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)–treated macaques and to …

… McCairn et al. identify a locus for initiating vocal tics in the nucleus accumbens, and knock-on
disrupted global networks are identified through PET imaging and electrophysiology. …

… 2231-415 ) to KW McCairn. The monkeys used in this research were in part provided by
the National BioResource Project “Japanese Monkeys” of the Ministry of Education, Culture, …