Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian
genomes. However, extrusion has not been visualized in vivo, and thus, its functional …

Internal friction, which reflects the “roughness” of the energy landscape, plays an important
role for proteins by modulating the dynamics of their folding and other conformational …

Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell
type. Here, we show that this chromatin architecture can be predicted de novo using …

Two unique 3D coordination polymers based on octahedral [Ln6] (Ln = Gd (1), Dy (2)) clusters
as nodes were synthesized, exhibiting a novel (3,12)-connected topology with the symbol …

The energy landscape used by nature over evolutionary timescales to select protein sequences
is essentially the same as the one that folds these sequences into functioning proteins, …

… We characterize the mutational changes in the functional interaction between HK/RR proteins
through evolutionarily conserved interactions between the HK dimerization and histidine …

A novel metal‐organic framework {[Zn(XL) 2 ](ClO 4 ) 2 ⋅6 H 2 O} n (XL=N,N′‐bicyclo[2.2.2]oct‐7‐ene‐2,3,5,6‐tetracarboxdiimide
bi(1,2,4‐triazole)) was synthesized and structurally …

Two novel 3D frameworks were synthesized, and further nanosized to form nanospheres.
Studies revealed that 2 is the first MOF-based luminescent sensor for detecting cyclohexane, …

Protein−protein interactions play a central role in cellular function. Improving the understanding
of complex formation has many practical applications, including the rational design of …

Embryonic diapause is a maternally controlled phenomenon. The molecule controlling the
onset of the phenomenon is unknown. We demonstrated that overexpression of microRNA let-…