Population stratification—allele frequency differences between cases and controls due to
systematic ancestry differences—can cause spurious associations in disease studies. We …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic
component. Susceptibility to disease has been linked with a region on chromosome 2q. …

Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …

Background Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1
and PTPN22 are well-established susceptibility loci, other genes that confer a modest level …

The genetic association of the major histocompatibility complex (MHC) to rheumatoid arthritis
risk has commonly been attributed to alleles in HLA-DRB1. However, debate persists …

Using the Immunochip custom SNP array, which was designed for dense genotyping of 186
loci identified through genome-wide association studies (GWAS), we analyzed 11,475 …

The major histocompatibility complex (MHC) is one of the most extensively studied regions
in the human genome because of the association of variants at this locus with autoimmune, …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease 1 characterized by
activation of the type I interferon (IFN) pathway 2 , 3 , 4 . Here we convincingly replicate …