User profiles for R. M. Costa
Rui M. CostaProfessor, Columbia University Verified email at columbia.edu Cited by 16868 |
Concurrent activation of striatal direct and indirect pathways during action initiation
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected
by a number of debilitating neurological disorders 1 , 2 , 3 , 4 . The prevailing model of basal …
by a number of debilitating neurological disorders 1 , 2 , 3 , 4 . The prevailing model of basal …
Chronic stress causes frontostriatal reorganization and affects decision-making
The ability to shift between different behavioral strategies is necessary for appropriate
decision-making. Here, we show that chronic stress biases decision-making strategies, affecting …
decision-making. Here, we show that chronic stress biases decision-making strategies, affecting …
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
The learning of new skills is characterized by an initial phase of rapid improvement in
performance and a phase of more gradual improvements as skills are automatized and …
performance and a phase of more gradual improvements as skills are automatized and …
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
Neurofibromatosis type I (NF1) is one of the most common single-gene disorders that causes
learning deficits in humans 1 . Mice carrying a heterozygous null mutation of the Nf1 gene (…
learning deficits in humans 1 . Mice carrying a heterozygous null mutation of the Nf1 gene (…
Start/stop signals emerge in nigrostriatal circuits during sequence learning
Learning new action sequences subserves a plethora of different abilities such as escaping
a predator, playing the piano, or producing fluent speech. Proper initiation and termination of …
a predator, playing the piano, or producing fluent speech. Proper initiation and termination of …
[HTML][HTML] Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions
Shifting between goal-directed and habitual actions allows for efficient and flexible decision
making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm, …
making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm, …
Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences
Chunking allows the brain to efficiently organize memories and actions. Although basal
ganglia circuits have been implicated in action chunking, little is known about how individual …
ganglia circuits have been implicated in action chunking, little is known about how individual …
Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
…, P Okulski, J Dzwonek, RM Costa… - Journal of …, 2006 - Soc Neuroscience
Matrix metalloproteinases (MMPs) are extracellular proteases that have well recognized roles
in cell signaling and remodeling in many tissues. In the brain, their activation and function …
in cell signaling and remodeling in many tissues. In the brain, their activation and function …
Dopamine neuron activity before action initiation gates and invigorates future movements
Deciding when and whether to move is critical for survival. Loss of dopamine neurons (DANs)
of the substantia nigra pars compacta (SNc) in patients with Parkinson’s disease causes …
of the substantia nigra pars compacta (SNc) in patients with Parkinson’s disease causes …
[HTML][HTML] Neurofibromin regulation of ERK signaling modulates GABA release and learning
We uncovered a role for ERK signaling in GABA release, long-term potentiation (LTP), and
learning, and show that disruption of this mechanism accounts for the learning deficits in a …
learning, and show that disruption of this mechanism accounts for the learning deficits in a …