User profiles for R. L. Saxl
 | Ruth SaxlThe Jackson Laboratory Verified email at JAX.org Cited by 555 |
[HTML][HTML] PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination
Meiotic recombination generates new genetic variation and assures the proper segregation
of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase …
of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase …
PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis
ED Parvanov, H Tian, T Billings, RL Saxl… - Molecular biology of …, 2017 - Am Soc Cell Biol
In mammals, meiotic recombination occurs at 1- to 2-kb genomic regions termed hotspots,
whose positions and activities are determined by PRDM9, a DNA-binding histone …
whose positions and activities are determined by PRDM9, a DNA-binding histone …
[HTML][HTML] Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage
Background Genetic recombination plays an important role in evolution, facilitating the
creation of new, favorable combinations of alleles and the removal of deleterious mutations by …
creation of new, favorable combinations of alleles and the removal of deleterious mutations by …
Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis
F Sun, Y Fujiwara, LG Reinholdt, J Hu, RL Saxl… - Chromosoma, 2015 - Springer
Developmental progress of germ cells through meiotic phases is closely tied to ongoing
meiotic recombination. In mammals, recombination preferentially occurs in genomic regions …
meiotic recombination. In mammals, recombination preferentially occurs in genomic regions …
Parameters affecting the restoration of activity to inactive mutants of thymidylate synthase via subunit exchange: Further evidence that thymidylate synthase is a half-of …
RL Saxl, LM Changchien, LW Hardy, F Maley - Biochemistry, 2001 - ACS Publications
In a previous study we demonstrated that Escherichia coli thymidylate synthase activity
could be restored completely by incubating basically inactive mutants of this enzyme at room …
could be restored completely by incubating basically inactive mutants of this enzyme at room …
Synthesis and biochemical characterization of a phosphorylated analogue of the response regulator CheB
CheB is a response regulator protein in the bacterial chemotaxis two-component signal
transduction pathway. Methylesterase CheB functions together with methyltransferase CheR to …
transduction pathway. Methylesterase CheB functions together with methyltransferase CheR to …
Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2'-deoxyuridine 5'-Monophosphate
Evidence is presented that 5-imidazolylpropynyl-2‘-deoxyuridine 5‘-monophosphate (IP-dUMP)
is a mechanism-based, irreversible inactivator of Escherichia coli thymidylate synthase (…
is a mechanism-based, irreversible inactivator of Escherichia coli thymidylate synthase (…
[HTML][HTML] A T4-phage deoxycytidylate deaminase mutant that no longer requires deoxycytidine 5′-triphosphate for activation
RG Keefe, GF Maley, RL Saxl, F Maley - Journal of Biological Chemistry, 2000 - ASBMB
A deoxycytidylate (dCMP) deaminase encoded in T4-bacteriophage DNA that is induced on
phage infection ofEscherichia coli was shown earlier (Maley, GF, Duceman, BW, Wang, AM, …
phage infection ofEscherichia coli was shown earlier (Maley, GF, Duceman, BW, Wang, AM, …
[HTML][HTML] Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice
JA Branca, BE Low, RL Saxl, JK Sargent, RA Doty… - Genes & …, 2020 - ncbi.nlm.nih.gov
Known as the guardian of the genome, transformation-related protein 53 (TRP53) is a well-known
tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a …
tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a …
A Trojan horse approach for silencing thymidylate synthase
DK West, DC Porter, RL Saxl, F Maley - Biochemistry, 2004 - ACS Publications
In this paper we present a new and possibly more effective way of inhibiting thymidylate
synthase (TS) in cells than through the use of substrate analogue inhibitors. An inactive double …
synthase (TS) in cells than through the use of substrate analogue inhibitors. An inactive double …