User profiles for R. L. Moritz
 | Robert MoritzProfessor, Institute for Systems Biology Verified email at systemsbiology.org Cited by 35234 |
Exosomes: proteomic insights and diagnostic potential
RJ Simpson, JWE Lim, RL Moritz… - Expert review of …, 2009 - Taylor & Francis
Exosomes are 40–100-nm diameter membrane vesicles of endocytic origin that are
released by most cell types upon fusion of multivesicular bodies with the plasma membrane, …
released by most cell types upon fusion of multivesicular bodies with the plasma membrane, …
[HTML][HTML] A high-stringency blueprint of the human proteome
…, C Pineau, U Kusebauch, RL Moritz… - Nature …, 2020 - nature.com
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP)
in 2010, creating an international framework for global collaboration, data sharing, quality …
in 2010, creating an international framework for global collaboration, data sharing, quality …
Trans‐Proteomic Pipeline, a standardized data processing pipeline for large‐scale reproducible proteomics informatics
Democratization of genomics technologies has enabled the rapid determination of genotypes.
More recently the democratization of comprehensive proteomics technologies is enabling …
More recently the democratization of comprehensive proteomics technologies is enabling …
[HTML][HTML] Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we
used coimmunoprecipitation and 2D immobilized pH gradient/SDS PAGE, followed by …
used coimmunoprecipitation and 2D immobilized pH gradient/SDS PAGE, followed by …
A cross-platform toolkit for mass spectrometry and proteomics
for processing and analyzing complex proteomics data sets in a platform-agnostic manner
has become critical. With version 3.0 of the ProteoWizard Toolkit8, we attempt to mitigate …
has become critical. With version 3.0 of the ProteoWizard Toolkit8, we attempt to mitigate …
Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core …
HUPO initiated the Plasma Proteome Project (PPP) in 2002. Its pilot phase has (1) evaluated
advantages and limitations of many depletion, fractionation, and MS technology platforms; (…
advantages and limitations of many depletion, fractionation, and MS technology platforms; (…
The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition
The ProteomeXchange (PX) Consortium of proteomics resources ( http://www.proteomexchange.org
) was formally started in 2011 to standardize data submission and dissemination of …
) was formally started in 2011 to standardize data submission and dissemination of …
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
…, LM Zugaro, RJ Simpson, RL Moritz… - Proceedings of the …, 1999 - National Acad Sciences
The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors
of several cytokine signal transduction pathways. Their expression is induced by cytokine …
of several cytokine signal transduction pathways. Their expression is induced by cytokine …
[HTML][HTML] HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
Inhibitor of apoptosis (IAP) proteins inhibit caspases, a function counteracted by IAP antagonists,
insect Grim, HID, and Reaper and mammalian DIABLO/Smac. We now demonstrate …
insect Grim, HID, and Reaper and mammalian DIABLO/Smac. We now demonstrate …
[HTML][HTML] Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein …
Exosomes are 40–100-nm-diameter nanovesicles of endocytic origin that are released from
diverse cell types. To better understand the biological role of exosomes and to avoid …
diverse cell types. To better understand the biological role of exosomes and to avoid …