User profiles for R. J. Muschel

Ruth Muschel

Professor of Oncology, University of Oxford
Verified email at oncology.ox.ac.uk
Cited by 28656

Liver metastases

…, P Brodt, PA Clavien, RJ Muschel… - Nature reviews Disease …, 2021 - nature.com
Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC is …

[HTML][HTML] Targeting the CCL2-CCR2 signaling axis in cancer metastasis

SY Lim, AE Yuzhalin, AN Gordon-Weeks, RJ Muschel - Oncotarget, 2016 - ncbi.nlm.nih.gov
The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its
association with the progression of cancer. Although first described as a chemotactic …

On the dual roles and polarized phenotypes of neutrophils in tumor development and progression

H Piccard, RJ Muschel, G Opdenakker - Critical reviews in oncology …, 2012 - Elsevier
Inconsistencies plague our understanding of the role of neutrophils in cancer and the literature
provides evidence for a duality in neutrophil activity on the outcome of cancer. Here, the …

Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis

…, AB Fisher, L Shientag, A Lee, RJ Muschel - Nature medicine, 2000 - nature.com
Metastasis is a frequent complication of cancer, yet the process through which circulating
tumor cells form distant colonies is poorly understood. We have been able to observe the steps …

[HTML][HTML] A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth

B Qian, Y Deng, JH Im, RJ Muschel, Y Zou, J Li… - PloS one, 2009 - journals.plos.org
Background The stromal microenvironment and particularly the macrophage component of
primary tumors influence their malignant potential. However, at the metastatic site the role of …

[PDF][PDF] miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors

…, Y Pan, R Panchakshari, P Gottipati, RJ Muschel… - Molecular cell, 2011 - cell.com
Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates
with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are …

[HTML][HTML] Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

…, MM Olcina, W Gillies McKenna, RJ Muschel… - Cell death & …, 2012 - nature.com
Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic
ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test …

Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction

…, EJ Bernhard, RS Weber, RJ Muschel - Clinical Cancer …, 2002 - AACR
Purpose: Locoregional recurrence is the dominant form of treatment failure in head and neck
(H&N) cancer. The epidermal growth factor receptor (EGFR) is frequently amplified in this …

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

…, JW Pollard, W Ruf, RJ Muschel - Blood, The Journal …, 2012 - ashpublications.org
Tissue factor (TF) expression by tumor cells correlates with metastasis clinically and
supports metastasis in experimental settings. However, the precise pathways coupling TF to …

Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and-9

Y Ding, D Xu, G Feng, A Bushell, RJ Muschel… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Mesenchymal stem cells (MSCs) are known to be capable of suppressing
immune responses, but the molecular mechanisms involved and the therapeutic potential of …