User profiles for R. H. Reeves
 | Roger H. ReevesProfessor Emeritus of Physiology and of Genetic Medicine Verified email at jhmi.edu Cited by 16391 |
A mouse model for Down syndrome exhibits learning and behaviour deficits
… Irving, NG, Citron, MP & Reeves, RH The positions of twelve simple sequence repeat
markers relative to reference markers on mouse chromosome 16. Mamm. Genome 4, 364- 367 (…
markers relative to reference markers on mouse chromosome 16. Mamm. Genome 4, 364- 367 (…
TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer
…, M Onizuka, T Kitamura, T Sekiya, RH Reeves… - Nature …, 2001 - nature.com
The existence of tumor-suppressor genes was originally demonstrated by functional
complementation through whole-cell and microcell fusion 1, 2. Transfer of chromosome 11 into a …
complementation through whole-cell and microcell fusion 1, 2. Transfer of chromosome 11 into a …
Down syndrome
Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most genetically …
clinical features commonly known as Down syndrome (DS). DS is among the most genetically …
Segmental trisomy as a mouse model for Down syndrome.
MT Davisson, C Schmidt, RH Reeves… - Progress in clinical …, 1993 - europepmc.org
Mice trisomic for Chromosome (Chr) 16 have been used extensively as an animal model for
human Down Syndrome (Trisomy 21). This system has drawbacks, however: trisomy for all …
human Down Syndrome (Trisomy 21). This system has drawbacks, however: trisomy for all …
Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
Down syndrome (DS) is the most common genetic cause of mental retardation and affects
many aspects of brain development. DS individuals exhibit an overall reduction in brain size …
many aspects of brain development. DS individuals exhibit an overall reduction in brain size …
A chromosome 21 critical region does not cause specific Down syndrome phenotypes
LE Olson, JT Richtsmeier, J Leszl, RH Reeves - Science, 2004 - science.org
The “Down syndrome critical region” (DSCR) is a chromosome 21 segment purported to
contain genes responsible for many features of Down syndrome (DS), including craniofacial …
contain genes responsible for many features of Down syndrome (DS), including craniofacial …
Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice
…, LL Baxter, RH Reeves - … dynamics: an official …, 2000 - Wiley Online Library
Mouse genetic models can be used to dissect molecular mechanisms that result in human
disease. This approach requires detection and demonstration of compelling parallels …
disease. This approach requires detection and demonstration of compelling parallels …
Characterization of viable bacteria from Siberian permafrost by 16S rDNA sequencing
T Shi, RH Reeves, DA Gilichinsky, EI Friedmann - Microbial ecology, 1997 - Springer
Viable bacteria were found in permafrost core samples from the Kolyma-Indigirka lowland of
northeast Siberia. The samples were obtained at different depths; the deepest was about 3 …
northeast Siberia. The samples were obtained at different depths; the deepest was about 3 …
[HTML][HTML] Understanding the basis for Down syndrome phenotypes
Down syndrome is a collection of features that are caused by trisomy for human Chromosome
21. While elevated transcript levels of the more than 350 genes on the chromosome are …
21. While elevated transcript levels of the more than 350 genes on the chromosome are …
Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome
Human trisomy 21, which results in Down syndrome (DS), is one of the most complicated
congenital genetic anomalies compatible with life, yet little is known about the molecular basis …
congenital genetic anomalies compatible with life, yet little is known about the molecular basis …