… (JD Siliciano, RF Siliciano, unpublished results). Eradication of the latent reservoir is likely
to require at least five or six logs of decay (10). With a half-life of 44 months, this would require …

HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected
cells are rare in vivo and appear to arise when activated CD4 + T cells, the major targets …

… also demonstrated that most latently infected cells have a CD45RO + phenotype (J Siliciano,
RF Siliciano, unpublished results), consistent with the mechanism proposed in Figure 2. …

The hypothesis that quiescent CD4 + T lymphocytes carrying proviral DNA provide a reservoir
for human immunodeficiency virus–type 1 (HIV-1) in patients on highly active antiretroviral …

Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels,
indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in …

The capacity of HIV-1 to establish latent infection of CD4 + T cells may allow viral persistence
despite immune responses and antiretroviral therapy. Measurements of infectious virus 1,2 …

Latent HIV-1 persists in resting memory CD4 + T cells, even in patients receiving highly active
antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and …

Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting
CD4 + T cells. T cell activation reverses latency, but <1% of proviruses are induced to …

Although it is presumed that the integration of HIV-1 into the genome of infected CD4 + T
lymphocytes allows viral persistence, there has been little direct evidence that CD4 + T cells …

Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot eliminate
the virus because HIV-1 establishes latent infection. Interruption of HAART leads to a …