User profiles for R. E. Lenski

Richard Lenski

Microbiology / EEB / Michigan State University
Verified email at msu.edu
Cited by 50219

The dynamics of molecular evolution over 60,000 generations

BH Good, MJ McDonald, JE Barrick, RE Lenski… - Nature, 2017 - nature.com
… Michael Desai, Richard Lenski and colleagues now report whole-genome sequencing at
500-generation intervals over the course of the 60,000 generations from the LTEE. Their …

Long-term experimental evolution in Escherichia coli. I. Adaptation and divergence during 2,000 generations

RE Lenski, MR Rose, SC Simpson… - The American …, 1991 - journals.uchicago.edu
… coli are T5 resistant (RE Lenski, unpublished data) and most laboratory strains (eg, K12) are
T6 sensitive. In addition, both naturally occurring and laboratory strains of E. coli are almost …

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

…, CZ Borland, RE Lenski - Proceedings of the …, 2008 - National Acad Sciences
RE Lenski, Experimental studies of pleiotropy and epistasis in Escherichia coli. II.
Compensation for maladaptive pleiotropic effects associated with resistance to virus T4. …

Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation

SF Elena, RE Lenski - Nature Reviews Genetics, 2003 - nature.com
Microorganisms have been mutating and evolving on Earth for billions of years. Now, a field
of research has developed around the idea of using microorganisms to study evolution in …

Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.

RE Lenski, M Travisano - Proceedings of the National …, 1994 - National Acad Sciences
We followed evolutionary change in 12 populations of Escherichia coli propagated for
10,000 generations in identical environments. Both morphology (cell size) and fitness (measured …

Genome dynamics during experimental evolution

JE Barrick, RE Lenski - Nature Reviews Genetics, 2013 - nature.com
Evolutionary changes in organismal traits may occur either gradually or suddenly. However,
until recently, there has been little direct information about how phenotypic changes are …

Genomic analysis of a key innovation in an experimental Escherichia coli population

ZD Blount, JE Barrick, CJ Davidson, RE Lenski - Nature, 2012 - nature.com
… Here we report the results of extensive whole-genome re-sequencing that allowed us to
reconstruct the population’s history, identify mutations underlying the Cit + phenotype, and …

Experimental evolution

TJ Kawecki, RE Lenski, D Ebert, B Hollis… - Trends in ecology & …, 2012 - cell.com
Experimental evolution is the study of evolutionary processes occurring in experimental
populations in response to conditions imposed by the experimenter. This research approach is …

Genome evolution and adaptation in a long-term experiment with Escherichia coli

…, SH Yoon, H Jeong, TK Oh, D Schneider, RE Lenski… - Nature, 2009 - nature.com
… Mutations in each genome were then identified using BRESEQ, a pipeline implemented in
Perl for analysing bacterial WGS re-sequencing data (JE Barrick, unpublished algorithm). The …

The planned introduction of genetically engineered organisms: ecological considerations and recommendations

…, RK Colwell, YL Grossman, RE Hodson, RE Lenski… - Ecology, 1989 - Wiley Online Library
… Such resistance could reduce the efficacy of engineering the Bt toxin into agricultural …
Lenski, RE 1987. The infectious spread of engineered genes. Pages 99-124 in JR Fowle, III, …