Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We …

… When necessary, samples were re-centred using the Nexus Express TM software, choosing
… For each gene, mRNA abundances were re-normalized and centred by the median across …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development 1 . The current model of …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq)
of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive …

… Re-clustering was performed on malignant cells using a method similar to that described
above. Each malignant cluster was scored for the top 100 ranked genes for all Classical- and …

Purpose: To determine the impact of basal-like and classical subtypes in advanced
pancreatic ductal adenocarcinoma (PDAC) and to explore GATA6 expression as a surrogate …

… ‘mixed-type inhibition’ of mutation detection sensitivity, which we examined by mixing
increasing proportions of normal sequence reads (17, 33 and 50%) into the tumour data set and re-…

Importance Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain
poor. Advances in next-generation sequencing provide a route to therapeutic approaches, …

We integrated clinical, genomic, and transcriptomic data from 224 primaries and 95 metastases
from 289 patients to characterize progression of pancreatic ductal adenocarcinoma (…