Identifying the signals that regulate stem cell differentiation is fundamental to understanding
cellular diversity in the brain. In this paper we identify factors that act in an instructive fashion …

Embryonic stem (ES) cells are clonal cell lines derived from the inner cell mass of the
developing blastocyst that can proliferate extensively in vitro and are capable of adopting all the …

A major difficulty in studying early developmental processes and testing hypotheses of
possible cellular mechanisms of development has been the inability to reproducibly identify …

Hypoxia contributes to the progression of a variety of cancers by activating adaptive
transcriptional programs that promote cell survival, motility and tumor angiogenesis. Although the …

Important features of adult neuronal number, location, and type are a consequence of early
embryonic events that occur before neurons have differentiated. We have measured cell …

Nestin is a recently described member of the intermediate filament (IF) protein family that is
especially abundant in neuroepithelial stem cells of the rat. The studies described here …

Many hypotheses for the specificity of connections in the nervous system postulate the
presence of surface chemical differences between neurons. Hybridoma technology offers a …

Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs)
represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and …

… We used a xenon 133 ('=Xe) clearance method of CBF determination during CPB
reported by McKay and associates [8] in 1983 and used by Henriksen and co-workers [9]. …

The monoclonal antibody Cat-301 was used to examine neurons in the cerebral cortex and
dorsal thalamus of several mammalian species, including Old World monkeys, cats, bush …