User profiles for R. D. Kouyos
Roger D. KouyosUniversity of Zurich; University Hospital Zurich Verified email at uzh.ch Cited by 7970 |
Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland
Background . Sequence data from resistance testing offer unique opportunities to characterize
the structure of human immunodeficiency virus (HIV) infection epidemics. Methods . We …
the structure of human immunodeficiency virus (HIV) infection epidemics. Methods . We …
A highly virulent variant of HIV-1 circulating in the Netherlands
…, HF Günthard, P Kivelä, RD Kouyos… - Science, 2022 - science.org
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred
nine individuals with this variant had a 0.54 to 0.74 log 10 increase (ie, a ~3.5-fold to 5.5-…
nine individuals with this variant had a 0.54 to 0.74 log 10 increase (ie, a ~3.5-fold to 5.5-…
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
…, ES Svarovskaia, H Mo, RD Kouyos… - Proceedings of the …, 2011 - National Acad Sciences
The development of resistance to direct-acting antivirals (DAAs) targeting the hepatitis C
virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and …
virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and …
[HTML][HTML] Determinants of HIV-1 broadly neutralizing antibody induction
Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet
basic aspects of their induction remain poorly understood. Here we report on viral, host and …
basic aspects of their induction remain poorly understood. Here we report on viral, host and …
Cohort profile update: the Swiss HIV cohort study (SHCS)
…, C Kahlert, A Trkola, RD Kouyos… - International journal …, 2022 - academic.oup.com
The Swiss HIV Cohort Study (SHCS) provides a unique research platform for clinical,
translational, epidemiological, social and basic research. The SHCS was established in 1988. It is …
translational, epidemiological, social and basic research. The SHCS was established in 1988. It is …
The state of affairs in the kingdom of the Red Queen
One of the most prominent hypotheses to explain the ubiquity of sex and recombination is
based on host–parasite interactions. Under the name of the Red Queen hypothesis (RQH), it …
based on host–parasite interactions. Under the name of the Red Queen hypothesis (RQH), it …
Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection
… We found that the WFM can reproduce the temporal increase of the fraction of ambiguous
sites for parameters that have been shown to reproduce neutral evolution in HIV (see Kouyos …
sites for parameters that have been shown to reproduce neutral evolution in HIV (see Kouyos …
[HTML][HTML] Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
…, E Bernasconi, M Cavassini, RD Kouyos… - Nature …, 2019 - nature.com
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host
characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on …
characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on …
Epistasis between deleterious mutations and the evolution of recombination
Epistasis and the evolution of recombination are closely intertwined: epistasis generates
linkage disequilibria (ie statistical associations between alleles), whereas recombination …
linkage disequilibria (ie statistical associations between alleles), whereas recombination …
Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized …
…, B Masquelier, P Bellecave, RD Kouyos… - Journal of …, 2015 - academic.oup.com
Objectives It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect
the virological outcomes of first-line NNRTI-containing ART. Methods This Europe-wide case…
the virological outcomes of first-line NNRTI-containing ART. Methods This Europe-wide case…