Epilepsy represents a major burden to society, not least because approximately 25% of
patients do not respond satisfactorily to antiepileptic medication, and only a minority with …

Neocortical epilepsy is frequently drug-resistant. Surgery to remove the epileptogenic zone
is only feasible in a minority of cases, leaving many patients without an effective treatment. …

… Rob Wykes (unpublished data). … ., 2013) and (Kullmann and Wykes, unpublished data). Such
devices might … Remote control of behavior through genetically targeted photostimulation of …

Pharmaceutical treatment can be inadequate, non-effective, or intolerable for many people
suffering from a neuronal channelopathy. Development of novel treatment options, …

Mapping the entire frequency bandwidth of brain electrophysiological signals is of paramount
importance for understanding physiological and pathological states. The ability to record …

Refractory focal epilepsy is a devastating disease for which there is frequently no effective
treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way …

Focal epilepsy involves excessive cortical activity that propagates both locally and distally.
Does this propagation follow the same routes as normal cortical activity? We …

Glioblastoma (GBM) is the most common and advanced form of primary malignant tumour
occurring in the adult central nervous system, and it is frequently associated with epilepsy, a …

Objective Loss of function of the astrocyte‐specific protein MLC1 leads to the childhood‐onset
leukodystrophy “megalencephalic leukoencephalopathy with subcortical cysts” (MLC). …

This technical note introduces adiabatic dynamic causal modelling, a method for inferring
slow changes in biophysical parameters that control fluctuations of fast neuronal states. The …