With the completion of the human genome sequence, attention turned to identifying and
annotating its functional DNA elements. As a complement to genetic and comparative genomics …

… Ross C Hardison … Ross C Hardison … Regions of noncoding DNA with a particularly
high similarity among species have long been recognized as good candidates for functional …

A ‘working draft' of the human genome sequence is now available. Comparisons with the
sequences of mouse and other species will be a powerful approach to identifying functional …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Accessing and analyzing the exponentially expanding genomic sequence and functional
data pose a challenge for biomedical researchers. Here we describe an interactive system, …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …

The Mouse Genome Analysis Consortium aligned the human and mouse genome sequences
for a variety of purposes, using alignment programs that suited the various needs. For …

The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from
the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and …

Eukaryotic chromosomes replicate in a temporal order known as the replication-timing
program 1 . In mammals, replication timing is cell-type-specific with at least half the genome …