Highlights • The GEs produce many types of GABAergic projection neurons and a majority
of GABAergic interneurons. • Spatial origin, birthdate, and mode of division influence …

Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of
their contributions to brain functions. Red light penetrates deeper into tissue than other …

Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse
brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic …

The regulation of fate decisions in progenitor cells lays the foundation for the generation of
neuronal diversity and the formation of specialized circuits with remarkable processing …

Objective— Defective autophagy in macrophages leads to pathological processes that
contribute to atherosclerosis, including impaired cholesterol metabolism and defective …

One of the hallmarks of the cerebral cortex is the extreme diversity of interneurons 1 , 2 – 3 .
The two largest subtypes of cortical interneurons, parvalbumin- and somatostatin-positive …

The medial ganglionic eminence (MGE) gives rise to the majority of mouse forebrain interneurons.
Here, we examine the lineage relationship among MGE-derived interneurons using a …

This Matters Arising Response paper addresses the Sultan et al. (2016) Matters Arising
paper, published concurrently in Neuron. Clonally related excitatory neurons maintain a …

Mutations accumulate in the genome of every cell of the body throughout life, causing cancer
and other genetic diseases 1–4. Almost all of these mosaic mutations begin as nucleotide …