Paraneoplastic Syndromes Involving the Nervous System | NEJM Skip to main content NEJM
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The US National Institute of Neurological Disorders and Stroke convened major stakeholders
in June 2012 to discuss how to improve the methodological reporting of animal studies in …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a
polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in …

… Jensen, KB & Darnell, RB CLIP: crosslinking and immunoprecipitation of in vivo RNA …
Acknowledgments We thank members of the Darnell laboratory for discussion, J. Fak for help with …

Exome sequencing of 343 families, each with a single child on the autism spectrum and at
least one unaffected sibling, reveal de novo small indels and point substitutions, which come …

… The authors are grateful to members of the Darnell and Ule laboratories and J. Richter for
critical discussions and review of the manuscript, B. Friedman for suggesting the use of exon …

… Zoghbi for helpful comments on the manuscript and members of the lab, especially JC
Darnell, BK Dredge, and G. Stefani, for their help and insight throughout this work. Supported by …

Fragile X syndrome results from the absence of the RNA binding FMR protein. Here, mRNA
was coimmunoprecipitated with the FMRP ribonucleoprotein complex and used to …

Loss of fragile X mental retardation protein (FMRP) function causes the fragile X mental
retardation syndrome. FMRP harbors three RNA binding domains, associates with polysomes, …