User profiles for R. A. Flynn

Ryan A Flynn

Stem Cell Program, Boston Children's Hospital | Stem Cell and Regenerative Biology …
Verified email at stanford.edu
Cited by 20149

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

…, Y Chen, BR Lajoie, A Protacio, RA Flynn, RA Gupta… - Nature, 2011 - nature.com
The genome is extensively transcribed into long intergenic noncoding RNAs (lincRNAs),
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …

A unique chromatin signature uncovers early developmental enhancers in humans

…, R Bajpai, T Swigut, SA Brugmann, RA Flynn… - Nature, 2011 - nature.com
Cell-fate transitions involve the integration of genomic information encoded by regulatory
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …

[HTML][HTML] c-Myc regulates transcriptional pause release

PB Rahl, CY Lin, AC Seila, RA Flynn, S McCuine… - Cell, 2010 - cell.com
Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters
by specific DNA-binding transcription factors is well recognized as a key regulatory step in …

Divergent transcription from active promoters

…, SS Levine, GW Yeo, PB Rahl, RA Flynn, RA Young… - science, 2008 - science.org
Transcription initiation by RNA polymerase II (RNAPII) is thought to occur unidirectionally
from most genes. Here, we present evidence of widespread divergent transcription at protein-…

[PDF][PDF] m6A RNA modification controls cell fate transition in mammalian embryonic stem cells

…, B Haddad, K Daneshvar, AC Carter, RA Flynn… - Cell stem cell, 2014 - cell.com
N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger RNAs and is
linked to human diseases, but its functions in mammalian development are poorly …

[PDF][PDF] Systematic discovery of Xist RNA binding proteins

C Chu, QC Zhang, ST Da Rocha, RA Flynn… - Cell, 2015 - cell.com
Noncoding RNAs (ncRNAs) function with associated proteins to effect complex structural and
regulatory outcomes. To reveal the composition and dynamics of specific noncoding RNA-…

Control of somatic tissue differentiation by the long non-coding RNA TINCR

…, J Chow, D Johnston, GE Kim, RC Spitale, RA Flynn… - Nature, 2013 - nature.com
Several of the thousands of human long non-coding RNAs (lncRNAs) have been
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …

HiChIP: efficient and sensitive analysis of protein-directed genome architecture

MR Mumbach, AJ Rubin, RA Flynn, C Dai, PA Khavari… - Nature …, 2016 - nature.com
Genome conformation is central to gene control but challenging to interrogate. Here we
present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of …

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

EJ Grow, RA Flynn, SL Chavez, NL Bayless… - Nature, 2015 - nature.com
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome 1 . The most recently acquired human ERV is HERVK(HML…

Structural imprints in vivo decode RNA regulatory mechanisms

RC Spitale, RA Flynn, QC Zhang, P Crisalli, B Lee… - Nature, 2015 - nature.com
Visualizing the physical basis for molecular behaviour inside living cells is a great challenge
for biology. RNAs are central to biological regulation, and the ability of RNA to adopt …