User profiles for R. A. Flynn
Ryan A FlynnStem Cell Program, Boston Children's Hospital | Stem Cell and Regenerative Biology … Verified email at stanford.edu Cited by 20149 |
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
The genome is extensively transcribed into long intergenic noncoding RNAs (lincRNAs),
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …
A unique chromatin signature uncovers early developmental enhancers in humans
Cell-fate transitions involve the integration of genomic information encoded by regulatory
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …
[HTML][HTML] c-Myc regulates transcriptional pause release
Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters
by specific DNA-binding transcription factors is well recognized as a key regulatory step in …
by specific DNA-binding transcription factors is well recognized as a key regulatory step in …
Divergent transcription from active promoters
Transcription initiation by RNA polymerase II (RNAPII) is thought to occur unidirectionally
from most genes. Here, we present evidence of widespread divergent transcription at protein-…
from most genes. Here, we present evidence of widespread divergent transcription at protein-…
[PDF][PDF] m6A RNA modification controls cell fate transition in mammalian embryonic stem cells
N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger RNAs and is
linked to human diseases, but its functions in mammalian development are poorly …
linked to human diseases, but its functions in mammalian development are poorly …
[PDF][PDF] Systematic discovery of Xist RNA binding proteins
Noncoding RNAs (ncRNAs) function with associated proteins to effect complex structural and
regulatory outcomes. To reveal the composition and dynamics of specific noncoding RNA-…
regulatory outcomes. To reveal the composition and dynamics of specific noncoding RNA-…
Control of somatic tissue differentiation by the long non-coding RNA TINCR
…, J Chow, D Johnston, GE Kim, RC Spitale, RA Flynn… - Nature, 2013 - nature.com
Several of the thousands of human long non-coding RNAs (lncRNAs) have been
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …
HiChIP: efficient and sensitive analysis of protein-directed genome architecture
Genome conformation is central to gene control but challenging to interrogate. Here we
present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of …
present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of …
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome 1 . The most recently acquired human ERV is HERVK(HML…
nearly 8% of the human genome 1 . The most recently acquired human ERV is HERVK(HML…
Structural imprints in vivo decode RNA regulatory mechanisms
Visualizing the physical basis for molecular behaviour inside living cells is a great challenge
for biology. RNAs are central to biological regulation, and the ability of RNA to adopt …
for biology. RNAs are central to biological regulation, and the ability of RNA to adopt …