R-loops are three-stranded nucleic acid structures that accumulate on chromatin in
neurological diseases and cancers and contribute to genome instability. Using a proximity-…

… We confirmed that at CTCF peaks called from control mESC samples, R-loop signal is
significantly (p < 2.2 3 10 À16 ) … Two-sided Student’st test p values are shown where applicable. …

R-loops are three-stranded nucleic acid structures with essential roles in many nuclear
processes. However, their unchecked accumulation is associated with genome instability and is …

Combination therapy with decitabine, a DNMTi and carboplatin resensitized chemoresistant
ovarian cancer (OC) to platinum inducing promising clinical activity. We investigated gene-…

… The same methods were used to compare the effects of the Mediterranean, Japanese, and
Maasai/ketogenic diets to the American diet, with P-values calculated using the American diet …

Heterochromatin in the eukaryotic genome is rigorously controlled by the concerted action
of protein factors and RNAs. Here, we investigate the RNA binding function of ATRX, a …

ATRX is a chromatin remodeler, which is mutated in ATRX syndrome, a neurodevelopmental
disorder. ATRX mutations that alter histone binding or chromatin remodeling activities …

In the study of DNA methylation, genetic variation between species, strains or individuals can
result in CpG sites that are exclusive to a subset of samples, and insertions and deletions …

Diet-related metabolic syndrome is the largest contributor to adverse health in the United
States. However, the study of gene-environment interactions and their epigenomic and …

5011 Background: Aberrant DNA methylation is a hallmark of cancer. Preclinical studies
showed that hypomethylating agents reverse Pt resistance, supporting testing low dose …