User profiles for P. Thielen

Peter M. Thielen

- Verified email at jhuapl.edu - Cited by 4366

Peter Thielen

- Verified email at ngc.com - Cited by 1835

The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration

…, F Lisbona, M Torres, C Leon, P Thielen… - Current molecular …, 2008 - ingentaconnect.com
The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell
survival under conditions of endoplasmic reticulum (ER) stress. The UPR controls diverse …

[PDF][PDF] Bracken: estimating species abundance in metagenomics data

J Lu, FP Breitwieser, P Thielen, SL Salzberg - PeerJ Computer Science, 2017 - peerj.com
… Note that because we began by assuming that a read was classified at node Gj, P(Gj)=1.
Next we consider how to compute P(Gj|Si), the probability that a read from genome Si will be …

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

C Hetz, P Thielen, S Matus, M Nassif… - Genes & …, 2009 - genesdev.cshlp.org
Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis (fALS).
Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) stress …

[PDF][PDF] BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1α

F Lisbona, D Rojas-Rivera, P Thielen, S Zamorano… - Molecular cell, 2009 - cell.com
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated
signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (…

Decoding dissolved information: environmental DNA sequencing at global scale to monitor a changing ocean

LR Thompson, P Thielen - Current Opinion in Biotechnology, 2023 - Elsevier
… Author links open overlay panel Luke R Thompson 1 2 , Peter Thielen 3 … Chapman, P.
Hugenholtz, EE Allen, RJ Ram, PM Richardson, VV Solovyev, EM Rubin, DS Rokhsar, JF Banfield …

Mid-wave IR and long-wave IR laser potential of rare-earth doped chalcogenide glass fiber

LB Shaw, B Cole, PA Thielen… - IEEE Journal of …, 2001 - ieeexplore.ieee.org
… PA Thielen is with Sachs Freeman Associates, Largo, MD 20774 USA. Publisher Item … PA
Thielen received the BS degree in physics from Harvey Mudd College, Claremont, CA, in 1996. …

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

RL Vidal, A Figueroa, FA Court, P Thielen… - Human molecular …, 2012 - academic.oup.com
Mutations leading to expansion of a poly-glutamine track in Huntingtin (Htt) cause Huntington's
disease (HD). Signs of endoplasmic reticulum (ER) stress have been recently reported in …

Active phase and polarization locking of a 1.4 kW fiber amplifier

…, JE Rothenberg, TS McComb, PA Thielen… - Optics letters, 2010 - opg.optica.org
… pulse is sufficiently fast that it transmits through the entire amplifier chain without being
affected by laser dynamics, so that there is a substantial, transient drop in the output power Δ P

[PDF][PDF] Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells

…, KK Park, L Yang, X Wei, Q Yang, KS Cho, P Thielen… - Neuron, 2012 - cell.com
Loss of retinal ganglion cells (RGCs) accounts for visual function deficits after optic nerve
injury, but how axonal insults lead to neuronal death remains elusive. By using an optic nerve …

[PDF][PDF] Regulation of memory formation by the transcription factor XBP1

…, FG Serrano, AO Ardiles, C Wirth, P Valdes, P Thielen… - Cell reports, 2016 - cell.com
Contextual memory formation relies on the induction of new genes in the hippocampus. A
polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for …