The microenvironment of solid tumours contains regions of poor oxygenation and high acidity.
Growing evidence from clinical and experimental studies points to a fundamental role for …

Recently, immunohistochemical analysis of myoglobin (MB) in human breast cancer specimens
has revealed a surprisingly widespread expression of MB in this nonmuscle context. The …

Firefly luciferase catalyzes the emission of light from luciferin in the presence of oxygen and
adenosine triphosphate. This bioluminescence is commonly employed in imaging mode to …

To test if proteolysis is involved in tumor cell extravasation, we developed an in vitro model
where tumor cells cross an endothelial monolayer cultured on a basement membrane. Using …

Spatial and temporal oxygen heterogeneity exists in most solid tumour microenvironments
due to an inadequate vascular network supplying a dense population of tumour cells. An …

Purpose: To determine the response of tumor suppressor p53 to hypoxia in different tumor
cell lines and the involvement of p53 activity regulation in the effect of hypoxia on tumor cell …

… OXPHOS capacity (P) was measured after addition of a saturating concentration of ADP (…
This is based on the result that P was nearly equivalent to E (P/E=0.97±0.01 SD in +IL3 cells…

The scientific community is bearing witness to the rise of a new method of literature dissemination,
the Open Access Publishing model. I believe the adoption and implementation of this …

Intracellular signaling pathways not only control cell proliferation and survival, but also
regulate the provision of cellular energy and building blocks through mitochondrial and …

provided by Elsevier-Publisher Connector physiological control of routine ATP demand was
0.41 of E. Similarly, the oligomycin-inhibited respiration (L; representing LEAK) which was …