Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

…, IP Newton, E Batlle, P Simon-Assmann… - Genes & …, 2004 - genesdev.cshlp.org
Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise
mechanism of this suppression remains to be defined. Using a novel inducible Ahcre …

Key Role of the Cdx2 Homeobox Gene in Extracellular Matrix–mediated Intestinal Cell Differentiation

…, I Duluc, AD Arcangelis, P Simon-Assmann… - The Journal of cell …, 1997 - rupress.org
To explore the role of homeobox genes in the intestine, the human colon adenocarcinoma
cell line Caco2-TC7 has been stably transfected with plasmids synthesizing Cdx1 and Cdx2 …

Extracellular matrix components in intestinal development

P Simon-Assmann, M Kedinger, A De Arcangelis… - Experientia, 1995 - Springer
Intestinal morphogenesis and differentiation are dependent on heterotypic cell interactions
between embryonic epithelial cells (endoderm) and stromal cells (mesenchyme). …

In vitro models of intestinal epithelial cell differentiation

P Simon-Assmann, N Turck, M Sidhoum-Jenny… - Cell biology and …, 2007 - Springer
… the crypt-villus axis: laminin-1 and laminin-2 are found in the proliferative crypt region while
laminin-5 and laminin10 are found underneath the differentiated cells (Simon-Assmann et al.…

[PDF][PDF] Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model

…, G Cremel, C Arnold, A Klein, P Simon-Assmann… - Cell reports, 2013 - cell.com
The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific
matrix, and high TNC expression is linked to poor prognosis in several cancers. To …

[PDF][PDF] Role of laminins in physiological and pathological angiogenesis

P Simon-Assmann, G Orend… - International journal of …, 2011 - academia.edu
… isoforms masks the function of the knocked out isoform (SimonAssmann et al., 2010).
Furthermore, since LM are heterotrimeric molecules, it is difficult to assign a conclusive function to …

[HTML][HTML] Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation

…, A Klein, WL Hicks, M Roux, P Simon-Assmann… - Journal of Biological …, 2010 - ASBMB
The Neuromutagenesis Facility at the Jackson Laboratory generated a mouse model of
retinal vasculopathy, nmf223, which is characterized clinically by vitreal fibroplasia and vessel …

Hemidesmosome integrity protects the colon against colitis and colorectal cancer

…, M Kedinger, I Van Seuningen, P Simon-Assmann… - Gut, 2017 - gut.bmj.com
Objective Epidemiological and clinical data indicate that patients suffering from IBD with
long-standing colitis display a higher risk to develop colorectal high-grade dysplasia. Whereas …

Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation

…, B Quistorff, P Simon-Assmann… - Physiological …, 2006 - journals.physiology.org
DNA-binding transcription factors bind to promoters that carry their binding sites. Transcription
factors therefore function as nodes in gene regulatory networks. In the present work we …

Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation.

…, O Lefebvre, M Kedinger, P Simon-Assmann - The Journal of cell …, 1996 - rupress.org
… Kedinger, and P. Simon-Assmann. 1994. Laminin expression is correlated to differentiation
SimonAssmann. 1992a. Dual and asynchronous deposition of laminin chains at the epitheliai…