Targeting genomic loci by massively parallel sequencing requires new methods to enrich
templates to be sequenced. We developed a capture method that uses biotinylated RNA 'baits' …

Learning to read and write the transcriptional regulatory code is of central importance to
progress in genetic analysis and engineering. Here we describe a massively parallel reporter …

… (combined P W = 1.5 × 10 −4 ) and when the single most informative base was mutated (P W
= … match score resulted in a significant increase in expression (P W = 5.6 × 10 −3 ). Neutral …

… Triangular heatmaps of tissue similarity are shown for the Pearson correlations of each
tested tissue set, and enrichment scores are represented as Àlog10 p values. Only cell types …

… higher genetic diversity for P. vivax relative to P. falciparum and discordant phylogeographical
histories for the two species 2 , likely caused, in part, by the unique ability of P. vivax to …

Targeted RNA-Seq combines next-generation sequencing with capture of sequences from
a relevant subset of a transcriptome. When testing by capturing sequences from a tumor …

… Data processing and statistical analysis, including computation of Pearson's and Spearman's
correlation coefficients, χ 2 -statistics and associated P-values, were performed using the …

… Notably, the sequences from bound sites with disrupted PPARγ motif sites showed higher
expression than sequences from the unbound genomic sites with the native PPARγ motifs (P …

… p i,L,r for r = 1, ..., RP values, and likewise for the p i,G P values. The P value p i we defined
to be p i = min(1,2 × min(p i,L , p i,… We multiply by two here to correct for having tested both P …

… We retrospectively sequenced the genomes of 194 P. falciparum isolates from five sites
in Northwest Thailand, over the period of a rapid increase in the emergence of artemisinin …