Patients with a primary cancer in the lung or in the upper aerodigestive tract have an
increased risk of developing synchronous or metachronous second primary lung tumors. This …

BACKGROUND: Women with BRCA1 or BRCA2 mutations are at increased risk of breast
and ovarian cancer. Oral contraceptives (OC) use has been associated with a reduction in …

The identification of germ-line mutations in 2 genes (BRCA1 and BRCA2) responsible for the
majority of hereditary ovarian cancers has led an increasing number of women carriers of …

The current availability of new Poly(ADP-ribose) Polymerase (PARP)-inhibitors for the treatment
of ovarian cancer patients independently of the presence of a BRCA pathogenic variant, …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. …

… ER-status of the first breast cancer was predictive of ER-status of asynchronous contralateral
breast cancer (P = 0.0004 for BRCA1; P = 0.002 for BRCA2). There were no significant …

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 …

… was no significant evidence of heterogeneity (P p .13). The … (RR p 0.53), and the ovarian
cancer risk was higher (RR p 3.1). … RR p 1.4 for breast cancer, and RR p 4.2 for ovarian cancer). …

… Breast-cancer risk was also significantly influenced by birth cohort (P<0.001) and by other
familial factors (P=0.04). The absolute breast-cancer risk for PALB2 female mutation carriers …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …