User profiles for P. Paschka
 | Peter PaschkaHaematologist, Professor (apl.), University Hospital of Ulm Verified email at klilu.de Cited by 22054 |
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized …
Recent molecular analyses of leukemic blasts from pretreatment marrow or blood of patients
with acute myeloid leukemia (AML) and a normal karyotype, the largest cytogenetic subset (…
with acute myeloid leukemia (AML) and a normal karyotype, the largest cytogenetic subset (…
[HTML][HTML] Genomic classification and prognosis in acute myeloid leukemia
…, L Bullinger, VI Gaidzik, P Paschka… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …
[PDF][PDF] IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid …
P Paschka, RF Schlenk, VI Gaidzik, M Habdank… - J Clin Oncol, 2010 - academia.edu
… IDH1andIDH2mutations contributed to the higher platelet counts; the difference in age was
attributed to IDH2 (P .001) and not to IDH1 mutations (P .60), whereas the difference in BM blasts …
attributed to IDH2 (P .001) and not to IDH1 mutations (P .60), whereas the difference in BM blasts …
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
…, K Holzmann, VI Gaidzik, P Paschka… - Blood, The Journal …, 2012 - ashpublications.org
… mutation in exon 6 (p.R213L) and an additional heterozygous frameshift mutation in exon
4 (p.A74fs), suggesting that these had occurred sequentially, with p.R213L being the primary …
4 (p.A74fs), suggesting that these had occurred sequentially, with p.R213L being the primary …
Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial
S Stilgenbauer, A Schnaiter, P Paschka… - Blood, The Journal …, 2014 - ashpublications.org
… SF3B1 mut was all missense, occurring most frequently as p.K700E/c.A2098G (48 of 114, …
P value columns compare outcome between subgroups defined by mutation status within 1 …
P value columns compare outcome between subgroups defined by mutation status within 1 …
[PDF][PDF] Adverse Prognostic Significance of KIT Mutations in Adult Acute Myeloid Leukemia With inv(16) and t(8;21): A Cancer and Leukemia Group B Study
… In inv(16), the cumulative incidence of relapse (CIR) was higher for patients with mutKIT (P …
In subset analyses, in addition to the aforementioned characteristics, patients with mutKIT17had …
In subset analyses, in addition to the aforementioned characteristics, patients with mutKIT17had …
[HTML][HTML] MicroRNA expression in cytogenetically normal acute myeloid leukemia
… -free survival in the training group (P<0.005). In the validation group, the … P=0.03). In
multivariable analysis, the microRNA summary value remained associated with event-free survival (P…
multivariable analysis, the microRNA summary value remained associated with event-free survival (P…
Differential impact of allelic ratio and insertion site in FLT3-ITD–positive AML with respect to allogeneic transplantation
… Increasing FLT3-ITD allelic ratio (P = .004) and IS in the tyrosine kinase domain 1 (TKD1,
P = .06) were associated with low complete remission (CR) rates. After postremission therapy …
P = .06) were associated with low complete remission (CR) rates. After postremission therapy …
An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia
Patients with cytogenetically normal acute myeloid leukemia (CN-AML) show heterogeneous
treatment outcomes. We used gene-expression profiling to develop a gene signature that …
treatment outcomes. We used gene-expression profiling to develop a gene signature that …
RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features
…, V Teleanu, E Papaemmanuil, D Weber, P Paschka… - Leukemia, 2016 - nature.com
We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic
impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid …
impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid …