Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

… promoter (P = 0.059). Error bars indicate sd, and experiments were performed in triplicate. …
We used the hypergeometric distribution to compute the P value of the associations with …

… Crispino, Thomas Trimarchi and the members of the Ntziachristos laboratory for critical
reading and helpful feedback on the manuscript. We apologize to those whose work could not be …

The past decade brought a revolution in understanding of the structure, topology and
disease-inducing lesions of RNA and DNA, fueled by unprecedented progress in next-generation …

Notch signaling is a key developmental pathway that is subject to frequent genetic and
epigenetic perturbations in many different human tumors. Here we investigate whether long …

… -wide JMJD3 occupancy is much lower, as a result of JMJD3 being concentrated in TSSs),
and compared with this control, we obtained an ∼7-fold enrichment of H3K4me3–JMJD3 (P < …

Sequencing efforts led to the identification of somatic mutations that could affect the self-renewal
and differentiation of cancer-initiating cells. One such recurrent mutation targets the …

Chromosomal rearrangements deregulating hematopoietic transcription factors are common
in acute lymphoblastic leukemia (ALL). Here we show that deregulation of the homeobox …

… the MYC promoter viewpoint as normalized read counts, and the negative y axis shows
the significance of differential interactions between T cells and CUTLL1 cells as the log 10 (P …

Transcription factors and chromatin-remodeling complexes are key determinants of embryonic
stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain …