The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …

Retrotransposons are mutagenic units able to move within the genome. Despite many defenses
deployed by the host to suppress potentially harmful activities of retrotransposons, these …

LINE-1s are active human DNA parasites that are agents of genome dynamics in evolution
and disease. These streamlined elements require host factors to complete their life cycles, …

KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a
longtime goal. Recently, inhibitors were developed that bind KRAS G12C -GDP and react with …

Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed after the disease has
metastasized; it is among the most lethal forms of cancer. We recently described aberrant …

… To investigate this further, Mita et al. used human cancer cells grown in the lab and tracked
LINE-1 during the different stages of the cell cycle. The results showed that LINE-1 enters the …

… At P < 0.03, we observed a correlation between ORF1p and ATM-targeted phosphosites
on both proteins: BRCA1-S1545 (S1524 in uniprot) (58) and NBN-S343 (59) (Fig. 5B). LINE-1 …

Transposable elements (TEs) represent a substantial fraction of many eukaryotic genomes,
and transcriptional regulation of these factors is important to determine TE activities in …

… , error = sd, two-tailed distribution homoscedastic t test, *P ≤ 0.05, **P ≤ 0.01) f, Scheme of
the modes of L1 … The P values intervals were reported in the corresponding figure legends. …

… A cut-off of p=10À3 for RNase-sensitivity is indicated by a light gray circle; proteins that
are RNase-sensitive with a statistical significance of p<10À3 are outside the circle. Proteins …