The ability to perturb genes in human cells is crucial for elucidating gene function and holds
great potential for finding therapeutic targets for diseases such as cancer. To extend the …

… log 10 (P) represents the −log 10 of the adjusted P value (FDR). Mean percentage overlap
refers to the mean of the percentage of overlapping core cancer-intrinsic CTL-evasion and …

… Ovarian cancer–specific essentials of note included the cyclin-dependent kinase CDK12 (P
5 0.015), which narrowly missed our P-value cutoff of P, 0.01, is involved in RNA splicing …

… Based on significant empirical screening evidence, we estimate ∼10% of genes to be
essential in a given cell line; the prior ratio P(essential)/P(nonessential) is therefore 0.1/0.9, which …

Aims Oral glucose-lowering medications are associated with excess risk of heart failure (HF).
Given the absence of comparative data among drug classes, we performed a retrospective …

MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …

… The sh1-CD83 knockdown tumors were >2-fold smaller than the tumors expressing the
negative control shLacZ (P=0.038) or the untransduced LIM1215 cells (P=0.0006; Figure 5M). …

… The greyscale colour legend for P values is indicated on the right; P values were
calculated using gProfileR 69 . h, Schematic depicting the function of selected FASN negative …

Macrophages can remove antigen from the surface of antibody-coated cells by a process
termed trogocytosis. Using live cell microscopy and flow cytometry, we investigated the …

… Changes were considered significant if they were greater than 10 dPSI/dPIR and the expected
minimum change was different from zero at p > 0.95 according to vast-tools’ diff module. …