… may account for differences in the studies of Lenschow (110) and Linsley (109) to induce …
Hellstrom, KE Hellstrom, JA Ledbetter, P. McGowan, PS Linsley. Costimulation of antitumor …

Small interfering RNAs (siRNAs) are widely used to study gene function owing to the ease
with which they silence target genes, and there is considerable interest in their potential for …

Antigen-specific T-ceil activation is initiated through the T-cell receptor. Recent evidence has
shown that a number of additional T-cell surface receptors serve to regulate the responses …

… 3) targets with the microarray data can be observed at weaker P values at the 24 h time
point (Supplementary Discussion), implying that our stringent P values, even while capturing a …

… Some 5,000 genes were significantly regulated across the group of samples (that is, at
least a twofold difference and a P-value of less than 0.01 in more than five tumours). …

A global decrease in microRNA (miRNA) levels is often observed in human cancers 1 , 2 ,
indicating that small RNAs may have an intrinsic function in tumour suppression. To identify …

RNA interference is thought to require near-identity between the small interfering RNA (siRNA)
and its cognate mRNA. Here, we used gene expression profiling to characterize the …

… under reducing conditions in the presence of P-mercaptoethanol. … closely parallels that
previously reported for activated human T cells (Linsley et al., 1992a): CTLA4 expression appears …

We describe a flexible system for gene expression profiling using arrays of tens of thousands
of oligonucleotides synthesized in situ by an ink-jet printing method employing standard …

THE receptor–ligand pairs CD28–B7 and CD40–gp39 are essential for the initiation and
amplification of T-cell-dependent immune responses 1,2 . CD28–B7 interactions provide '…