User profiles for P. Krusche

Peter Krusche

Novartis
Verified email at novartis.com
Cited by 2671

[BOOK][B] Ökologisches bauen

P Krusche, D Althaus, I Gabriel, M Weig-Krusche - 2019 - books.google.com
Die Aufgabe, mit dem hauszuhalten und auszukommen, was uns die Natur an erneuterten
Ressourcen gibt, und das Aufbrauchen nicht erneuerbarer Naturschätze auf ein Mindestmaß …

Strelka2: fast and accurate calling of germline and somatic variants

…, M Källberg, X Chen, Y Kim, D Beyter, P Krusche… - Nature …, 2018 - nature.com
P(D|F t , F n ) is decomposed by sample to P(D t |F t )P(D n |F … -specific allele frequency
likelihoods P(D t |F t ) and P(D n |F … P(G t , G n ) and the joint allele-frequency distribution P(F t , F …

Best practices for benchmarking germline small-variant calls in human genomes

P Krusche, L Trigg, PC Boutros, CE Mason… - Nature …, 2019 - nature.com
… Partly on the basis of feedback from the challenges, an improved benchmarking app ‘GA4GH
Benchmarking’ uploaded by user peter.krusche is now available on PrecisionFDA, and …

A reference data set of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree

MA Eberle, E Fritzilas, P Krusche, M Källberg… - Genome …, 2017 - genome.cshlp.org
… Most (91%) of the SNVs in this category are clustered at specific locations in the genome
and also deviate significantly (P < 0.01) from Hardy Weinberg Equilibrium (HWE) in a …

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle

C Feillet, P Krusche, F Tamanini… - Proceedings of the …, 2014 - National Acad Sciences
… of the coupling and the size of p and q (when p:q is expressed in lowest-order terms) and
decreases very rapidly as p and q become larger. Although p:q phase locking with p,q > 1 is …

ExpansionHunter: a sequence-graph-based tool to analyze variation in short tandem repeat regions

…, V Deshpande, F Schlesinger, P Krusche… - …, 2019 - academic.oup.com
We describe a novel computational method for genotyping repeats using sequence graphs.
This method addresses the long-standing need to accurately genotype medically important …

Quantity discrimination in salamanders

P Krusche, C Uller, U Dicke - Journal of Experimental …, 2010 - journals.biologists.com
We investigated discrimination of large quantities in salamanders of the genus Plethodon.
Animals were challenged with two different quantities (8 vs 12 or 8 vs 16) in a two-alternative …

[HTML][HTML] Paragraph: a graph-based structural variant genotyper for short-read sequence data

S Chen, P Krusche, E Dolzhenko, RM Sherman… - Genome biology, 2019 - Springer
… For each SV, we used Fisher’s exact test to calculate its Hardy-Weinberg p values [49].
SVs with p value less than 0.0001 were considered as HWE-failed. We used dosage of HWE-…

[HTML][HTML] Heritability of chronic venous disease

A Fiebig, P Krusche, A Wolf, M Krawczak, B Timm… - Human genetics, 2010 - Springer
… V A of the phenotypic variance V P in a population that is … In our study, however, only a small
yet significant difference (P = 9.2Χ10 −… effect upon BMI (P = 7.8Χ10 −6 and P = 2.2Χ10 −16 ). …

Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants

…, R Hickman, J Moore, C Barrington, P Krusche… - The Plant …, 2012 - academic.oup.com
Conserved noncoding sequences ( CNSs ) in DNA are reliable pointers to regulatory
elements controlling gene expression. Using a comparative genomics approach with four …