Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

…, AF Caulin, J St John, AR Cordero, P Giannikopoulos… - Nature …, 2017 - nature.com
… of EGFR p.Thr790Met in EGFR TKI-naive patients (0.5%) 12 , it is likely that most of these
EGFR p.… We found an increase in the mean number of detectable genetic alterations in EGFR p.…

The Impact of EGFR T790M Mutations and BIM mRNA Expression on Outcome in Patients with EGFR-Mutant NSCLC Treated with Erlotinib or Chemotherapy in the …

…, S Viteri, M Taron, M Ono, P Giannikopoulos… - Clinical cancer …, 2014 - AACR
… those with low/intermediate BCL2L11 expression (P = 0.0364). Multivariate analyses showed
that erlotinib was a marker of longer PFS (HR = 0.35; P = 0.0003), whereas high BCL2L11 …

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism

JH Lee, P Giannikopoulos, SA Duncan, J Wang… - Nature medicine, 2011 - nature.com
… but were completely absent from the 238 controls (P = 0.01, two-sided Fisher's exact test, …
of 238 control versus 12 of 449 hypertriglyceridemia, P = 0.22). All mutations localized to the …

[HTML][HTML] Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA …

…, L Ambrogio, SL Carter, K Cibulskis, P Giannikopoulos… - Oncogene, 2014 - nature.com
Pleuropulmonary blastoma is a rare childhood malignancy of lung mesenchymal cells that
can remain dormant as epithelial cysts or progress to high-grade sarcoma. Predisposing …

Association of Upper Respiratory Streptococcus pneumoniae Colonization With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Adults

…, EA Moehle, P Giannikopoulos… - Clinical Infectious …, 2023 - academic.oup.com
Background Streptococcus pneumoniae interacts with numerous viral respiratory pathogens
in the upper airway. It is unclear whether similar interactions occur with severe acute …

Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3CβD1067V kinase domain mutation

E Pazarentzos, P Giannikopoulos, G Hrustanovic… - Oncogene, 2016 - nature.com
Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs widely in human cancers.
Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN are known to …

[HTML][HTML] Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus

…, C Sherry, A Harte, G Nicolette, P Giannikopoulos… - PLoS …, 2021 - journals.plos.org
Regular surveillance testing of asymptomatic individuals for SARS-CoV-2 has been center
to SARS-CoV-2 outbreak prevention on college and university campuses. Here we describe …

Association of upper respiratory Streptococcus pneumoniae colonization with SARS-CoV-2 infection among adults

…, NB Brennick, EA Moehle, P Giannikopoulos… - medRxiv, 2022 - medrxiv.org
Background Streptococcus pneumoniae interacts with numerous viral respiratory pathogens
in the upper airway. It is unclear whether similar interactions occur with SARS-CoV-2. …

[HTML][HTML] Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples

…, G Huberty, FD Urnov, P Giannikopoulos… - PloS one, 2021 - journals.plos.org
Saliva is an attractive specimen type for asymptomatic surveillance of COVID-19 in large
populations due to its ease of collection and its demonstrated utility for detecting RNA from …

Rhabdomyosarcoma: how advanced molecular methods are shaping the diagnostic and therapeutic paradigm

P Giannikopoulos, DM Parham - Pediatric and …, 2021 - journals.sagepub.com
… The author(s) declared the following potential conflicts of interest with respect to the
research, authorship, and/or publication of this article: Petros Giannikopoulos, MD is a co-founder …