Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we …

We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–…

Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid
and lymphoid features, limited genetic characterization, and a lack of consensus regarding …

… Loss of the positive charge due to the p.Arg60Gln substitution is expected to weaken DNA
interactions. NONO forms … We found both MYCN amplification and activating p.Pro44Leu or …

… of the covariates we considered (P > .05). In contrast, BL signature C was found to be
significantly associated with tumor EBV status (P = .038), but not clinical variant status (P = .23), …

… A P value was determined by Wilcoxon rank-sum test for A and Kruskal–Wallis test for B. …
A P value was determined by Wilcoxon rank-sum test for A and Kruskal–Wallis test for B. …

Cervical cancer is the most common cancer affecting sub-Saharan African women and is
prevalent among HIV-positive (HIV + ) individuals. No comprehensive profiling of cancer …

Contribution: EEP organized and analyzed the data, created the figure, and reviewed the
manuscript; JAKH performed that ADAMTS13 measurements and reviewed the manuscript; …

Mutations in the FLT3 gene are among the most common somatic events in AML, with a
higher prevalence in adults than in children. The most common activating mutations of FLT3 …

Introduction: Although recent studies have refined the classification of B-progenitor and T-lineage
acute lymphoblastic leukemia into gene-expression based subgroups, a …