Methane is an important greenhouse gas, responsible for about 20% of the warming induced
by long-lived greenhouse gases since pre-industrial times. By reacting with hydroxyl …

Carotenoids are isoprenoid molecules that are widespread in nature and are typically seen
as pigments in fruits, flowers, birds and crustacea. Animals are unable to synthesise …

Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However, compound …

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1,
also known as γ chain (γc) deficiency] in 9 out of 10 patients by retrovirus-mediated γc …

Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very aggressive …

WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has substantial
nucleotide and amino-acid sequence similarity to the S182 gene on chromosome 14q24.…

… Similarly, at 23 weeks, performance during a visible platform test and spontaneous
exploration of the open field were not significantly influenced by immunization (P > 0.05). Gender …

… The results showed small but significant increases in total human Aß peptides in the
hippocampus of the Tg29 M146L (P < 0.001) and Tg198 L286V (P < 0.01) double-transgenic mice …

We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of
familial Alzheimer's disease mutations on amyloid β-peptide (Aβ) biogenesis. TgCRND8 mice …

… Fraser and co-workers have shown that the protofilaments formed by Aβ peptides
assemble into hollow rods or ribbons of various sizes under different conditions of pH (…