User profiles for P. Deelen
Patrick DeelenPost-doc researcher at University Medical Center Groningen Verified email at umcg.nl Cited by 13266 |
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…
on the transcriptome. To investigate the genetics of gene expression, we performed cis…
[HTML][HTML] Mapping the human genetic architecture of COVID-19
…, A Renieri, VG Sankaran, D van Heel, P Deelen… - Nature, 2021 - nature.com
The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …
infection. Although environmental, clinical and social factors have a role in the chance of …
The effect of host genetics on the gut microbiome
The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …
assessed the influence of host genetics on microbial species, pathways and gene ontology …
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
While many disease-associated variants have been identified through genome-wide association
studies, their downstream molecular consequences remain unclear. To identify these …
studies, their downstream molecular consequences remain unclear. To identify these …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …
experiments to understand their functional consequences 1 , 2 . Identification of expression …
Identification of context-dependent expression quantitative trait loci in whole blood
Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology 1 , 2 . Expression quantitative trait loci (eQTLs) help to explain the …
on disease etiology 1 , 2 . Expression quantitative trait loci (eQTLs) help to explain the …
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based
cohort shows relations between the microbiome and 126 exogenous and intrinsic host …
cohort shows relations between the microbiome and 126 exogenous and intrinsic host …
[HTML][HTML] The Genome of the Netherlands: design, and project goals
Within the Netherlands a national network of biobanks has been established (Biobanking and
Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the …
Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the …
[HTML][HTML] Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the …
For many complex traits, genetic variants have been found associated. However, it is still
mostly unclear through which downstream mechanism these variants cause these phenotypes. …
mostly unclear through which downstream mechanism these variants cause these phenotypes. …
[PDF][PDF] A functional genomics approach to understand variation in cytokine production in humans
…, M Jaeger, R Aguirre-Gamboa, KTT Le, P Deelen… - Cell, 2016 - cell.com
As part of the Human Functional Genomics Project, which aims to understand the factors that
determine the variability of immune responses, we investigated genetic variants affecting …
determine the variability of immune responses, we investigated genetic variants affecting …