User profiles for P. Deelen

Patrick Deelen

Post-doc researcher at University Medical Center Groningen
Verified email at umcg.nl
Cited by 13266

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

…, A Claringbould, HJ Westra, MJ Bonder, P Deelen… - Nature …, 2021 - nature.com
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

[HTML][HTML] Mapping the human genetic architecture of COVID-19

…, A Renieri, VG Sankaran, D van Heel, P Deelen… - Nature, 2021 - nature.com
The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …

The effect of host genetics on the gut microbiome

…, Z Mujagic, F Imhann, AV Vila, P Deelen… - Nature …, 2016 - nature.com
The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …

Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

…, A Claringbould, HJ Westra, MJ Bonder, P Deelen… - BioRxiv, 2018 - biorxiv.org
While many disease-associated variants have been identified through genome-wide association
studies, their downstream molecular consequences remain unclear. To identify these …

Disease variants alter transcription factor levels and methylation of their binding sites

…, R Luijk, DV Zhernakova, M Moed, P Deelen… - Nature …, 2017 - nature.com
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

Identification of context-dependent expression quantitative trait loci in whole blood

DV Zhernakova, P Deelen, M Vermaat, M Van Iterson… - Nature …, 2017 - nature.com
Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology 1 , 2 . Expression quantitative trait loci (eQTLs) help to explain the …

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

…, SA Jankipersadsing, M Joossens, MC Cenit, P Deelen… - Science, 2016 - science.org
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based
cohort shows relations between the microbiome and 126 exogenous and intrinsic host …

[HTML][HTML] The Genome of the Netherlands: design, and project goals

…, H Byelas, AJM De Craen, P Deelen… - European journal of …, 2014 - nature.com
Within the Netherlands a national network of biobanks has been established (Biobanking and
Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the …

[HTML][HTML] Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the …

…, HJ Westra, D Arends, MJ Bonder, J Fu, P Deelen… - PLoS …, 2011 - journals.plos.org
For many complex traits, genetic variants have been found associated. However, it is still
mostly unclear through which downstream mechanism these variants cause these phenotypes. …

[PDF][PDF] A functional genomics approach to understand variation in cytokine production in humans

…, M Jaeger, R Aguirre-Gamboa, KTT Le, P Deelen… - Cell, 2016 - cell.com
As part of the Human Functional Genomics Project, which aims to understand the factors that
determine the variability of immune responses, we investigated genetic variants affecting …