… Indeed, six of ten patients with NSD1 mutations in LUSC were within the NSD1 subtype (Chi-squared
P = 0.005). This mirrors the phenotype of a similar hypomethylated, NSD1-…

DNA methylation is an important epigenetic mechanism regulating gene expression and its
role in carcinogenesis has been extensively studied. High-throughput DNA methylation …

Angiogenesis is involved in chronic inflammatory joint diseases such as rheumatoid arthritis
(RA). Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis. The …

… Levels were higher in HLA B-27 negative patients (p = 0.02). No statistical correlation was
found between p40 IL12/40 serum levels and each of BASDAI, ESR, CRP, serum levels of IL …

… Mean age at the diagnosis of AS was 33 years in the cases and 30 years in the controls (P
= 0.30). Mean age at the diagnosis of discitis in the cases was 40 years. We found no …

… The only positive correlation was between the ESR and the CRP level (P=0.0002).
Thirteen patients were evaluated 10 weeks into TNFα antagonist therapy (adalimumab, n=7; …

… lumbar spine BMD (P = 0.01) (corresponding T score: P = 0.03), but femoral neck BMD did
not differ significantly between AS and controls (P = 0.08) (corresponding T score: P = 0.11). …

… three groups (P = 0.19… P = 0.01 and P<0.0001, respectively). The femoral neck and total
body BMD and the lean mass were lower in RA compared with HC (P = 0.0004, P<0.0001 and P …

A prospective study of the prevalence of bronchiectasis in rheumatoid arthritis was conducted
over an 18-month period in 46 patients (34 women and 12 men with a mean age of 60.1 …

… No differences were found between patients and controls in cytoplasmic (P = 0.8) or nuclear
(P = 0.5) Sirt1 activity (Table 1). There was no correlation between Sirt1 activity (nuclear and …