Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients <50 years old) has increased at an alarming rate. Although robust and scientifically …

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor
genes. To catalog the genetic changes that occur during tumorigenesis, we isolated …

The elucidation of the human genome sequence has made it possible to identify genetic
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …

Mounting evidence indicates that Smad proteins are required for TGFβ signaling, but the
way(s) in which Smad proteins propagate this signal is unclear. We found that two human …

To gain insights into the molecular basis for metastasis, we compared the global gene
expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal …

… CA19–9 (area under the receiver operating characteristic curve, 0.81 and 0.77, respectively),
and the combination of MIC-1 and CA19–9 significantly improved diagnostic accuracy (P < …

Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most
aggressive breast cancer subtype. Here we identify hypoxia-induced ECM re-modeler, lysyl …

Purpose: Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the tumor growth
factor β (TGF-β) superfamily. Several observations suggest that it plays a role in colorectal …

Serial analysis of gene expression was used to identify transcripts encoding secreted or cell
surface proteins that were expressed in benign and malignant tumors of the colorectum. A …

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma
identified somatic mutations in 23% of melanomas. Five mutations in one of the most …