[HTML][HTML] Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
L Baitsch, P Baumgaertner, E Devêvre… - The Journal of …, 2011 - Am Soc Clin Investig
… Microarray analysis was done with relatively restrictive criteria, ie, by considering gene
probes as significant if the P value, corrected for a FDR of 0.05, was P ≤ 0.05 and the fold …
probes as significant if the P value, corrected for a FDR of 0.05, was P ≤ 0.05 and the fold …
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
…, PG Foukas, P Baumgaertner… - Proceedings of the …, 2015 - National Acad Sciences
… with melanoma (***P < 0.001 for pairwise comparisons between … for all E:T ratios tested; P
value not significant for pairwise … P < 0.01 and ***P < 0.001, unpaired two-tailed Student t test). …
value not significant for pairwise … P < 0.01 and ***P < 0.001, unpaired two-tailed Student t test). …
Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data
… In addition to p and C we also define pà and CÃ, which are the same except that they
include the normalized proportions and profiles from the reference cell types only (ie they have …
include the normalized proportions and profiles from the reference cell types only (ie they have …
Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab
…, L Cagnon, CM Costa-Nunes, P Baumgaertner… - Cancer Immunology …, 2014 - Springer
Metastatic melanoma has a poor prognosis with high resistance to chemotherapy and radiation.
Recently, the anti-CTLA-4 antibody ipilimumab has demonstrated clinical efficacy, being …
Recently, the anti-CTLA-4 antibody ipilimumab has demonstrated clinical efficacy, being …
Association of checkpoint inhibitor–induced toxic effects with shared cancer and tissue antigens in non–small cell lung cancer
…, R Niederer, CJ Ackermann, P Baumgaertner… - JAMA …, 2019 - jamanetwork.com
… Pearson correlation coefficient was R = 0.71 for nivolumab and R = 0.81 for
pembrolizumab, and the P value was P = .003 for nivolumab and P = .001 for pembrolizumab. …
pembrolizumab, and the P value was P = .003 for nivolumab and P = .001 for pembrolizumab. …
[HTML][HTML] Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization
…, SA Fuertes Marraco, JP Rivals, P Baumgaertner… - PloS one, 2012 - journals.plos.org
… p-values of the permutation test are shown in tables next to the corresponding pie charts. Co…
p-values of the permutation test are shown in tables next to the corresponding pie charts. (B) …
p-values of the permutation test are shown in tables next to the corresponding pie charts. (B) …
Nano‐particle vaccination combined with TLR‐7 and ‐9 ligands triggers memory and effector CD8+ T‐cell responses in melanoma patients
…, R Dummer, P Baumgaertner… - European journal of …, 2012 - Wiley Online Library
… Mel Q b G 10 is a virus‐like nano‐particle loaded with A ‐type C p G ‐oligonucleotides ( C
p G ‐ … We conclude that the simultaneous use of both I miquimod and C p G ‐ ODN induced …
p G ‐ … We conclude that the simultaneous use of both I miquimod and C p G ‐ ODN induced …
[HTML][HTML] Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors
…, L Queiroz, P Baumgaertner, P Guillaume… - Nature …, 2023 - nature.com
The success of cancer immunotherapy depends in part on the strength of antigen recognition
by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) …
by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) …
Memory and effector CD8 T-cell responses after nanoparticle vaccination of melanoma patients
DE Speiser, K Schwarz, P Baumgaertner… - Journal of …, 2010 - journals.lww.com
Induction of cytotoxic CD8 T-cell responses is enhanced by the exclusive presentation of
antigen through dendritic cells, and by innate stimuli, such as toll-like receptor ligands. On the …
antigen through dendritic cells, and by innate stimuli, such as toll-like receptor ligands. On the …
[HTML][HTML] SHP-1 phosphatase activity counteracts increased T cell receptor affinity
…, P Baumgaertner, P Romero… - The Journal of …, 2013 - Am Soc Clin Investig
Anti-self/tumor T cell function can be improved by increasing TCR-peptide MHC (pMHC) affinity
within physiological limits, but paradoxically further increases (K d < 1 μM) lead to drastic …
within physiological limits, but paradoxically further increases (K d < 1 μM) lead to drastic …