Understanding the mechanisms of early embryonic patterning and the timely allocation of
specific cells to embryonic regions and fates as well as their development into tissues and …

The emergence of multiple axes is an essential element in the establishment of the mammalian
body plan. This process takes place shortly after implantation of the embryo within the …

… The aggregates needed to be in suspension for shape changes to occur (Baillie-Johnson et
… well, minimising the possibility of fusions (for details see Baillie-Johnson et al., 2014). The …

… Only embryonic cell types with at least one cluster comparison with a P value below 0.2
are shown. Using different P value thresholds to define upregulated genes does not have a …

The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo
development. In mammals, genetic studies have shown that this process relies on signals …

… Furthermore, using a recently developed 3D culture system of mESCs (Baillie-Johnson et
al., 2014; van den Brink et al., 2014), we show that a similar treatment of cell aggregates …

We have developed a protocol improving current Embryoid Body (EB) culture which allows
the study of self-organization, symmetry breaking, axial elongation and cell fate specification …

… somitic mesoderm upon transplantation (Baillie-Johnson et al., … along the anteroposterior
axis (Baillie-Johnson et al., 2018). … progenitors by fate mapping (Baillie-Johnson et al., 2018) …

Mouse embryonic stem cells (mESCs) can form all of the tissues of the developing embryo
in vivo; yet they develop into spatially disorganised structures when grown in vitro as …

Generation of asymmetry within the early embryo is a critical step in the establishment of the
three body axes, providing a reference for the patterning of the organism. To study the …