Background: The differential effectiveness of parent training has led researchers to examine
a variety of child, parent, and familial variables that may predict treatment response. Studies …

Objective: This report describes the participants and compares the acute and longer-term
treatment outcomes associated with each of four successive steps in the Sequenced Treatment …

OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression,
but the rates, timing, and baseline predictors of remission in “real world” patients are …

Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Background The value of nephrectomy in metastatic renal-cell cancer has long been debated.
Several nonrandomized studies suggest a higher rate of response to systemic therapy …

This study examined concurrent self-reports of pain intensity and behavioral responses in 25
children aged 3–7 yr. Behavioral (Children's Hospital of Eastern Ontario Pain Scale, cheops…

Chronic and recurrent pain not associated with a disease is very common in childhood and
adolescence, but studies of pain prevalence have yielded inconsistent findings. This …

Remission rates for Major Depressive Disorder (MDD) are low and unpredictable for any
given antidepressant. No biological or clinical marker has demonstrated sufficient ability to …

Objective. To provide recommendations for the core outcome domains that should be considered
by investigators conducting clinical trials of the efficacy and effectiveness of treatments …