Archaeal and eukaryotic homologs of Hfq: A structural and evolutionary perspective on Sm function
Hfq and other Sm proteins are central in RNA metabolism, forming an evolutionarily
conserved family that plays key roles in RNA processing in organisms ranging from archaea to …
conserved family that plays key roles in RNA processing in organisms ranging from archaea to …
Out-of-register parallel β-sheets and antiparallel β-sheets coexist in 150-kDa oligomers formed by amyloid-β (1–42)
We present solid-state NMR measurements of β-strand secondary structure and inter-strand
organization within a 150-kDa oligomeric aggregate of the 42-residue variant of the …
organization within a 150-kDa oligomeric aggregate of the 42-residue variant of the …
[HTML][HTML] Characterizing the resolution and throughput of the Apollo direct electron detector
R Peng, X Fu, JH Mendez, PS Randolph… - Journal of Structural …, 2023 - Elsevier
Advances in electron detection have been essential to the success of high-resolution cryo-EM
structure determination. A new generation of direct electron detector called the Apollo, has …
structure determination. A new generation of direct electron detector called the Apollo, has …
Geological and taphonomic context for the new hominin species Homo naledi from the Dinaledi Chamber, South Africa
10.7554/eLife.09561.001 We describe the physical context of the Dinaledi Chamber within
the Rising Star cave, South Africa, which contains the fossils of Homo naledi. Approximately …
the Rising Star cave, South Africa, which contains the fossils of Homo naledi. Approximately …
[HTML][HTML] Earliest hominin cancer: 1.7-million-year-old osteosarcoma from Swartkrans Cave, South Africa
… An invasive spinal lesion has been attributed by Randolph-Quinney and colleagues to benign
osteoid … EJO and PS.RQ wrote the original draft of the manuscript, incorporating additional …
osteoid … EJO and PS.RQ wrote the original draft of the manuscript, incorporating additional …
[HTML][HTML] Crystal structure and RNA-binding properties of an Hfq homolog from the deep-branching Aquificae: conservation of the lateral RNA-binding mode
KA Stanek, J Patterson-West, PS Randolph… - … Section D: Structural …, 2017 - scripts.iucr.org
The host factor Hfq, as the bacterial branch of the Sm family, is an RNA-binding protein
involved in the post-transcriptional regulation of mRNA expression and turnover. Hfq facilitates …
involved in the post-transcriptional regulation of mRNA expression and turnover. Hfq facilitates …
[HTML][HTML] Osteogenic tumour in Australopithecus sediba: Earliest hominin evidence for neoplastic disease
We describe the earliest evidence for neoplastic disease in the hominin lineage. This is
reported from the type specimen of the extinct hominin Australopithecus sediba from Malapa, …
reported from the type specimen of the extinct hominin Australopithecus sediba from Malapa, …
[HTML][HTML] Evidence of fatal skeletal injuries on Malapa Hominins 1 and 2
Malapa is one of the richest early hominin sites in Africa and the discovery site of the hominin
species, Australopithecus sediba. The holotype and paratype (Malapa Hominin 1 and 2, or …
species, Australopithecus sediba. The holotype and paratype (Malapa Hominin 1 and 2, or …
[HTML][HTML] Possible bite-induced abscess and osteomyelitis in Lufengosaurus (Dinosauria: sauropodomorph) from the Lower Jurassic of the Yimen Basin, China
L Xing, BM Rothschild, PS Randolph-Quinney… - Scientific reports, 2018 - nature.com
We report an osseous abnormality on a specimen of the sauropod dinosaur Lufengosaurus
huenei from the Fengjiahe Formation in Yuxi Basin, China. A gross pathological defect …
huenei from the Fengjiahe Formation in Yuxi Basin, China. A gross pathological defect …
Comment on “Deliberate body disposal by hominins in the Dinaledi Chamber, Cradle of Humankind, South Africa?”[J. Hum. Evol. 96 (2016) 145–148]
In responding to Val (2016), we welcome the opportunity to further clarify our interpretations
of the taphonomic and geological context of Homo naledi in the Dinaledi Chamber of the …
of the taphonomic and geological context of Homo naledi in the Dinaledi Chamber of the …