… Kaeser, pp 333-363 … Kaeser and Wade G. Regehr … We thank members of the Kaeser
and Regehr Labs and Dr. R. Zucker for critical comments on the manuscript. …

Dopamine is a prototypical neuromodulator that controls circuit function through G protein-coupled
receptor signalling. Neuromodulators are volume transmitters, with release followed …

… We thank members of the Kaeser, Biederer, and Blanpied labs, particularly Drs. Aihui Tang
and Haiwen Chen, for fruitful discussions and valuable comments on the manuscript. This …

At a synapse, fast synchronous neurotransmitter release requires localization of Ca 2+ channels
to presynaptic active zones. How Ca 2+ channels are recruited to active zones, however…

Synapses are fundamental information-processing units of the brain, and synaptic dysregulation
is central to many brain disorders ("synaptopathies"). However, systematic annotation of …

At presynaptic active zones, neurotransmitter release is initiated by the opening of voltage-gated
Ca 2+ channels close to docked vesicles. The mechanisms that enrich Ca 2+ channels …

New-variant Creutzfeldt–Jakob disease and scrapie are typically initiated by extracerebral
exposure to the causative agent, and exhibit early prion replication in lymphoid organs 1, 2. In …

At a synapse, the presynaptic active zone mediates synaptic vesicle exocytosis. RIM proteins
are active zone scaffolding molecules that—among others—mediate vesicle priming and …

Endocannabinoids (eCBs) have emerged as key activity-dependent signals that, by activating
presynaptic cannabinoid receptors (ie, CB1) coupled to G i/o protein, can mediate short-…

Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity
and throughput. Here we report immunostaining with signal amplification by exchange …