… PS Freemont, unpublished; see Table I). In all of these RING variants, the substituted amino
acids could participate in zinc ligation and, thus, the overall threedimensional structure of …

Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein
function. Recent results implicate the RING finger domain in specific ubiquitination events; it is …

… AJ Saurin, PS Freemont, unpublished data) and CART1 where Cyst is replaced by an aspartic
acid residue [20]. Again, other aspects of the RING motif are conserved, including the core …

Background The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading
globally, including in populations with high vaccination rates. We aimed to investigate …

The tumor-suppressive promyelocytic leukemia (PML) protein of acute promyelocytic
leukemia (APL) has served as one of the defining components of a class of distinctive nuclear …

… Co-transfection studies of these mutants with PML-RARα however, prevents the formation
of PML-RARα speckles (E Duprez and P Freemont, unpublished observations), suggesting a …

The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion
of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of PML …

p97, an abundant hexameric ATPase of the AAA family, is involved in homotypic membrane
fusion. It is thought to disassemble SNARE complexes formed during the process of …

High-resolution crystal structures of editing complexes of both duplex and single-stranded
DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four …

Acute promyelocytic leukaemia (APL) has been ascribed to a chromosomal translocation
event which results in a fusion protein comprising the PML protein and the retinoic acid …