Fatal familial insomnia (FFI) and a subtype of familial Creutzfeldt-Jakob disease (CJD), two
clinically and pathologically distinct diseases, are linked to the same mutation at codon 178 (…

… that the fidelity of coexistent ribozymal and protein aaRS translation will necessarily be
compromised by, and hence that purifying selection will eliminate, the less faithful of the two. …

The PRNP gene, encoding the amyloid precursor protein that is centrally involved in
Creutzfeldt-Jakob disease (CJD), has an unstable region of five variant tandem octapeptide coding …

… and T Pr (u) is critically dependent on the genes G(u) being maintained in the RNA population.
We will neglect the effects of ribozymal mutants T Ri (s) and protein variants T Pr (v). The …

… It is hoped that this volume will be a resource to all users in the field. As always, users in
the AUC field can keep in contact with the latest developments via the RASMB notice board (http:…

… The tRNA acceptor stem bases that determine which class of aaRS will acylate its terminal
adenosine do not furnish any obvious clues as to how this determination might initially have …

This chapter analyzes the epistemology of science in a way that makes it comparable with
other knowledge traditions of the peoples of the Pacific; a task made difficult by the claim of …

… We hope this synthesis of modular and sequence phylogeny will contribute to an eventual
understanding of how protein folding coevolved with the growth of the coding table itself. …

… must be interdependent; 2) reflexivity intrinsic to polypeptide aaRS production dynamics
promotes bootstrapping; 3) takeover of RNA-catalyzed aminoacylation by enzymes will …

… of using stepwise regression to select models from a larger number of predictors than
dependent variables—as is the case if we consider all two-way interactions—is that there will …