Polycomb and Trithorax group proteins encode the epigenetic memory of cellular positional
identity by establishing inheritable domains of repressive and active chromatin within the …

… PP Rocha is supported by an ASH fellowship. R Bonneau is supported by the Simons
Foundation. JA Skok is a Leukemia and Lymphoma Society (LLS) scholar and is supported by …

How enhancers activate their distal target promoters remains incompletely understood.
Here we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions. …

Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing methylation
of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a system whereby …

The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically
important for proper sister chromatid separation during mitosis. Mutations in the cohesin …

The Mediator complex is commonly seen as a molecular bridge that connects DNA-bound
transcription factors to the RNA polymerase II (Pol II) machinery. It is a large complex of 30 …

Imaging systems that allow visualization of specific loci and nuclear structures are highly
relevant for investigating how organizational changes within the nucleus play a role in …

We present herein a short-term impact on marketed fisheries and human health safety in the
first three months following the 2019 oil spill in Brazil. Total PAHs in the edible tissues of 34 …

Hematopoietic-specific transcription factors require coactivators to communicate with the
general transcription machinery and establish transcriptional programs that maintain …

Fate-determining transcription factors (TFs) can promote lineage-restricted transcriptional
programs from common progenitor states. The inner cell mass (ICM) of mouse blastocysts co-…