With the advent of combined immunotherapies, personalized dendritic cell (DC)-based
vaccination could integrate the current standard of care for the treatment of a large variety of …

Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides presented
by the major histocompatibility complex (pMHC) on the surface of professional antigen-…

INTRODUCTION: Our goal was to study the hormonal regulation of immune cell infiltration in
prostate cancer patients treated by androgen deprivation therapy (ADT) using an optimized …

The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a
central role in our ability to understand and predict (neo-)antigen presentation in infectious …

Efficient and persisting immune memory is essential for long-term protection from infectious
and malignant diseases. The yellow fever (YF) vaccine is a live attenuated virus that …

In deoxycorticosterone acetate (DOCA)-salt hypertension, the endothelin-1 system is activated
and plays a role in cardiac fibrosis. Remodeling of extracellular matrix (ECM) may lead to …

Several types of collagen contain cryptic antiangiogenic noncollagenous domains that are
released upon proteolysis of extracellular matrix (ECM). Among those is Arresten, a collagen-…

Increased density of tumor-associated lymphatic vessels correlates with poor patient
survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an …

Background Prostate cancer (PCa) is the most frequently diagnosed cancer in North American
men. Androgen-deprivation therapy (ADT) accentuates the infiltration of immune cells …

Background Most ovarian cancer patients are diagnosed at a late stage with 85% of them
relapsing after surgery and standard chemotherapy; for this reason, new treatments are …